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2-Deoxy-D-glucose

Product ID D1859
Cas No. 154-17-6
Purity ≥99%
Product Unit SizeCostQuantityStock
1 g $93.30 In stock
5 g $314.20 In stock
25 g $1,306.10 In stock
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  • Product Info
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  • Description
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Description

2-deoxy-D-glucose inhibits glucose metabolism and is used as a biomarker of glucose metabolism, hypoxia, and angiogenesis in a variety of models and cell types, including neurotoxicity, cancer, and autoimmune disease; the 2-OH group of glucose is replaced by a hydrogen and therefore this compound can not be metabolized properly. 2-deoxy-D-glucose inhibits N-linked glycosylation and glycolysis, inhibiting surface expression of MICA/B and other NKG2D ligands on cells. This compound also exhibits anticancer and pro-oxidative activities, increasing oxidative stress and mimicking glucose deprivation, resulting in cell death of cancer cells.

Product Info

Cas No.

154-17-6

Purity

≥99%

Formula

C6H12O5

Formula Wt.

164.16

IUPAC Name

(2S,4S,5S,6S)-6-(hydroxymethyl)oxane-2,4,5-triol

Melting Point

146-147°C

Appearance

White to slight yellow powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D1859 MSDS PDF

Info Sheet

D1859 Info Sheet PDF

References

Kaira K, Murakami H, Endo M, et al. Biological correlation of (18)F-FDG uptake on PET in pulmonary neuroendocrine tumors. Anticancer Res. 2013 Oct;33(10):4219-28. PMID: 24122985.

Andresen L, Skovbakke SL, Persson G, et al. 2-deoxy D-glucose prevents cell surface expression of NKG2D ligands through inhibition of N-linked glycosylation. J Immunol. 2012 Feb 15;188(4):1847-55. PMID: 22227571.

Shutt DC, O'Dorisio MS, Aykin-Burns N, et al. 2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells. Cancer Biol Ther. 2010 Jun 1;9(11):853-61. PMID: 20364116.

Nowak M, Carrasquillo JA, Yarboro CH, et al. A pilot study of the use of 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography to assess the distribution of activated lymphocytes in patients with systemic lupus erythematosus. Arthritis Rheum. 2004 Apr;50(4):1233-8. PMID: 15077306.

Böhmer R, Rommel K. The behaviour of different markers of the mucosal extracellular space in rat small intestine. Acta Hepatogastroenterol (Stuttg). 1975 Dec;22(6):398-403. PMID: 1211066.

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