Description
Abemaciclib is a CDK4 and CDK6 inhibitor found to inhibit retinoblastoma phosphorylation, leading to G1/S arrest in ER+ breast cancer cells and to promote metabolic alterations in metastatic HR+ breast cancer cells.
Product Unit Size | Cost | Quantity | Stock |
---|
Abemaciclib is a CDK4 and CDK6 inhibitor found to inhibit retinoblastoma phosphorylation, leading to G1/S arrest in ER+ breast cancer cells and to promote metabolic alterations in metastatic HR+ breast cancer cells.
Cas No. | 1231929-97-7 |
---|---|
Purity | ≥98% |
Formula | C27H32F2N8 |
Formula Wt. | 506.61 |
Chemical Name | N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine |
IUPAC Name | N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine |
Synonym | LY2835219 |
Solubility | 10 mM in DMSO; Soluble in dilute Acidic solution. Insoluble in Water |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Torres-Guzman R, Calsina B, Hermoso A, et al. Preclinical characterization of abemaciclib in hormone receptor positive breast cancer. Oncotarget. 2017 May 10. Epub ahead of print. PMID: 28537883
Tate SC, Burke TF, Hartman D, et al. Optimising the combination dosing strategy of abemaciclib and vemurafenib in BRAF-mutated melanoma xenograft tumours. Br J Cancer. 2016 Mar 15;114(6):669-679. PMID: 26978007
Knudsen ES, Hutcheson J, Vail P, et al. Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature. Oncotarget. 2017 Jun 10. Epub ahead of print. PMID: 28620137
Targets nuclear factor kappa B activation.
Endogenous neuropeptide hormone, lowers extrace...
ERK1/2 inhibitor.
Peptide, GLP-1 analog found in Heloderma; GLP-1...
Natriuretic, vasodilatory peptide fragment; B1/...
Polyphenol found in Camilla sinensis; HIV integ...
Imidazole; 14-α demethylase inhibitor, potenti...
ITC found in Nasturtium officinale (watercress)...
Respiratory toxin, mitochondrial permeability t...
GABA analog; GABA potentiator, adenosine A1 ago...
Histamine H2 inverse agonist.
HSP90 inhibitor.
HDAC inhibitor. May reduce blood pressure in hy...
Endogenous tachykinin peptide, involved in infl...
Coccidiostat.
Impurity of diclofenac
Hydantoin derivative; RyR antagonist, L-type Ca...
Catechol-type flavonoid.
LRRK2 inhibitor.
1,8-Diaza-anthracene-tetrone; JNK and ERK5 inhi...