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Azelnidipine

Product ID A9617
Cas No. 123524-52-7
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $61.50 In stock
10 mg $107.30 In stock
50 mg $465.10 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Azelnidipine is a dihydropyridine L-type Ca2+ channel blocker that exhibits antihypertensive, anti-atherosclerotic, and anti-inflammatory activities. Clinically, azelnidipine decreases blood pressure; it also decreases inflammatory cytokine levels and carotid intima-media thickness. Additionally, this compound preserves insulin signaling and glucose uptake in animal models of oxidative stress.

Product Info

Cas No.

123524-52-7

Purity

≥98%

Formula

C33H34N4O6

Formula Wt.

582.66

Chemical Name

3-(1-Benzhydrylazetidin-3-yl) 5-isopropyl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

IUPAC Name

3-[1-(Diphenylmethyl)-3-azetidinyl] 5-isopropyl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate

Synonym

CS-905, RS-9054

Solubility

15 mg/ml in ethanol, 30 mg/ml in DMSO and DMF. sparingly soluble in aqueous buffers.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A9617 MSDS PDF

Info Sheet

A9617 Info Sheet PDF

References

Tawaramoto K, Kaneto H, Hashiramoto M, et al. Azelnidipine, but not amlodipine, reduces urinary albumin excretion and carotid atherosclerosis in subjects with type 2 diabetes: blood pressure control with olmesartan and azelnidipine in Type 2 diabetes (BOAT2 study). Diabetol Metab Syndr. 2015 Sep 17;7:80. PMID: 26388951.

Tatsumi F, Kaneto H, Hashiramoto M, et al. Anti-hypertensive azelnidipine preserves insulin signaling and glucose uptake against oxidative stress in 3T3-L1 adipocytes. Endocr J. 2015;62(8):741-7. PMID: 26073866.

Chen BL, Zhang YZ, Luo JQ, et al. Clinical use of azelnidipine in the treatment of hypertension in Chinese patients. Ther Clin Risk Manag. 2015 Feb 24;11:309-18. PMID: 25750535.

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