Description
Chalcone is an enone on which a variety of structures are based. Chalcone derivatives typically exhibit anti-inflammatory, antioxidative, neuroprotective, analgesic, anticancer, and anti-parasitic activities.
Chalcone is an enone on which a variety of structures are based. Chalcone derivatives typically exhibit anti-inflammatory, antioxidative, neuroprotective, analgesic, anticancer, and anti-parasitic activities.
Cas No. | 94-41-7 |
---|---|
Purity | ≥97% |
Formula | C15H12O |
Formula Wt. | 208.26 |
Chemical Name | 1,3-Diphenyl-2-propen-1-one |
IUPAC Name | (E)-1,3-diphenylprop-2-en-1-one |
Synonym | Chalkone, trans-Benzylideneacetophenone |
Melting Point | 54-57°C |
Solubility | Insoluble in water. Slightly soluble in ethanol. |
Appearance | Light Yellow Crystal Powder |
Store Temp | Ambient |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Wu JZ, Cheng CC, Shen LL, et al. Synthetic Chalcones with Potent Antioxidant Ability on H2O2-Induced Apoptosis in PC12 Cells. Int J Mol Sci. 2014 Oct 14;15(10):18525-18539. PMID: 25318055.
Jantan I, Bukhari SN, Adekoya OA, et al. Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines. Drug Des Devel Ther. 2014 Sep 16;8:1405-18. PMID: 25258510.
Abdellatif KR, Elshemy HA, Salama SA, et al. Synthesis, characterization and biological evaluation of novel 4'-fluoro-2'-hydroxy-chalcone derivatives as antioxidant, anti-inflammatory and analgesic agents. J Enzyme Inhib Med Chem. 2014 Sep 8:1-8. PMID: 25198887.
Karthikeyan C, Narayana Moorthy NS, Ramasamy S, et al. Advances in Chalcones with Anticancer Activities. Recent Pat Anticancer Drug Discov. 2014 Aug 19. [Epub ahead of print]. PMID: 25138130.
Shivahare R, Korthikunta V, Chandasana H, et al. Synthesis, structure-activity relationships, and biological studies of chromenochalcones as potential antileishmanial agents. J Med Chem. 2014 Apr 24;57(8):3342-57. PMID: 24635539.
Respiratory toxin, mitochondrial permeability t...
N-acetyl cysteine conjugate of phenethylisothio...
Coumarin; VKORC1 inhibitor.
Type A trichothecene mycotoxin produced by Fusa...
Aromatase inhibitor.
PI3K inhibitor.
Aminoglycoside; protein translation inhibitor.<...
Used to prevent chromium deficiency and to decr...
Endogenous peptide hormone derived from POMC, i...
Stem cell neurogenesis inducer.
5-HT3 antagonist.
Benzyl taxol analog; potential microtubule depo...
Flavonoid found in species of Citrus; COX-2 inh...
Phenol found in Zingiber; 5-HT3 antagonist.
Furanocoumarin found in Psoralea coryfolia, DNA...
JAK1/2 inhibitor.
Fermentation impurity
Opioid peptide; μOR agonist.
Isocitrate dehydrogenase inhibitor.