Description
Defactinib inhibits FAK and displays anticancer activity. In ovarian cancer models, this compound decreases cell proliferation, induces apoptosis, and decreases tumor weight.
Product Unit Size | Cost | Quantity | Stock |
---|
Defactinib inhibits FAK and displays anticancer activity. In ovarian cancer models, this compound decreases cell proliferation, induces apoptosis, and decreases tumor weight.
Cas No. | 1073154-85-4 |
---|---|
Purity | ≥98% |
Formula | C20H21F3N8O3S |
Formula Wt. | 510.49 |
IUPAC Name | N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide |
Synonym | VS-6063, PF-04554878 |
Solubility | DMSO 5 mg/mL warmed (9.79 mM) Water Insoluble Ethanol Insoluble |
Appearance | White to off white powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Lee BY, Timpson P, Horvath LG, et al. FAK signaling in human cancer as a target for therapeutics. Pharmacol Ther. 2015 Feb;146C:132-149. PMID: 25316657.
Kang Y, Hu W, Ivan C, et al. Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer. J Natl Cancer Inst. 2013 Oct 2;105(19):1485-95. PMID: 24062525.
Fluoroquinolone, S-(-) isomer of ofloxacin; top...
Aminoglycoside; protein translation inhibitor.<...
NNK precursor found in tobacco smoke; carcinoge...
Cyclosporin metabolite; weak calmodulin inhibit...
Mixture of oligomycins A, B, C; oxidative phosp...
Carotenoid terpene pigment found in various pla...
BRG1/BRM ATPase inhibitor
Endogenous opioid peptide derived from the β-c...
D2 and 5-HT1A partial agonist, 5-HT2C/6/7 antag...
Peptide, HIV-1 RT A2.1 epitope.
Orexin 2 receptor antagonist
Polyphenol found in many plants and foods.
Mycotoxin produced by Fusarium fungi that infec...
Fluoroquinolone; bacterial DNA gyrase inhibitor...
Semi-synthetic vinca alkaloid found in Catharan...
Triphenylthylene, tamoxifen analog; SERM.
σ1 antagonist.
Prodrug
Antimicrobial peptide found in frogs, induces p...
EGFR (WT, T790M) inhibitor.