Diacerein is an anthraquinone that exhibits antinociceptive, anti-inflammatory, and anti-resorptive activities. Diacerein is clinically used to treat osteoarthritis. In vivo, diacerein inhibits IL-1β as well as somatic nociception induced by glutamate, NMDA, and kainate. In vitro, diacerein decreases expression of matrix metalloproteinase 13 (MMP13), cathepsin K, ERK1/2, and p38 MAPK, resulting in decreases in the synthesis of resorptive factors and in osteoclast formation. In other cellular models, diacerein inhibits IL-1.