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Formononetin

Product ID F5770
Cas No. 485-72-3
Purity ≥90%
Product Unit SizeCostQuantityStock
100 mg $92.50 In stock
500 mg $277.70 In stock
1 g $463.00 In stock
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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Formononetin is a phytoestrogen and isoflavone originally found in legumes in the Fabaceae family. Formononetin exhibits anti-inflammatory, antioxidative, anticancer, antihypertensive, anti-parasitic, anti-osteoporotic, and pro-angiogenic activities. Formononetin decreases expression of COX-2, malondialdehyde, TNF-α, and IL-6 and increases activity of superoxide dismutase and glutathione peroxidase in animal models of traumatic brain injury. In prostate cancer cells, formononetin increases expression of Bax and suppresses expression of IGF-1R, inducing apoptosis and inhibiting proliferation. In spontaneously hypertensive rats, formononetin decreases systolic blood pressure, increases expression of eNOS, and decreases expression of 5-HT receptors and α1-adrenergic receptors. Additionally, formononetin inhibits attachment and motility of Giardia. This compound also induces mesenchymal stem cell differentiation, increases expression of VEGF and VEGFR2, and promotes bone fracture healing.

Product Info

Cas No.

485-72-3

Purity

≥90%

Formula

C16H12O4

Formula Wt.

268.26

Chemical Name

7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one

IUPAC Name

7-hydroxy-3-(4-methoxyphenyl)chromen-4-one

Synonym

Biochanin B, Formononetol, Neochanin

Melting Point

258°C

Solubility

Soluble in DMSO (200mg/mL) or methanol (2mg/mL).

Appearance

Fine white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

F5770 MSDS PDF

Info Sheet

F5770 Info Sheet PDF

Brochures

Natural Products Booklet

References

Li Z, Dong X, Zhang J, et al. Formononetin protects TBI rats against neurological lesions and the underlying mechanism. J Neurol Sci. 2014 Mar 15;338(1-2):112-7. PMID: 24411660.

Huang WJ, Bi LY, Li ZZ, et al. Formononetin induces the mitochondrial apoptosis pathway in prostate cancer cells via downregulation of the IGF-1/IGF-1R signaling pathway. Pharm Biol. 2013 Dec 20. [Epub ahead of print]. PMID: 24359236.

Sun T, Wang J, Huang LH, et al. Antihypertensive effect of formononetin through regulating the expressions of eNOS, 5-HT2A/1B receptors and α1-adrenoceptors in spontaneously rat arteries. Eur J Pharmacol. 2013 Jan 15;699(1-3):241-9. PMID: 23123056.

Lauwaet T, Andersen Y, Van de Ven L, et al. Rapid detachment of Giardia lamblia trophozoites as a mechanism of antimicrobial action of the isoflavone formononetin. J Antimicrob Chemother. 2010 Mar;65(3):531-4. PMID: 20067984.

Huh JE, Kwon NH, Baek YH, et al. Formononetin promotes early fracture healing through stimulating angiogenesis by up-regulating VEGFR-2/Flk-1 in a rat fracture model. Int Immunopharmacol. 2009 Nov;9(12):1357-65. PMID: 19695348.

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