Description
GDC-0623 is an inhibitor of MEK that prevents MEK-dependent B-Raf and KRAS signaling. GDC-0623 exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a potential treatment for several cancers.
Product Unit Size | Cost | Quantity | Stock |
---|
GDC-0623 is an inhibitor of MEK that prevents MEK-dependent B-Raf and KRAS signaling. GDC-0623 exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a potential treatment for several cancers.
Cas No. | 1168091-68-6 |
---|---|
Purity | ≥98% |
Formula | C16H14FIN4O3 |
Formula Wt. | 456.21 |
IUPAC Name | 5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide |
Solubility | DMSO 91 mg/mL warmed (199.46 mM) Ethanol 5 mg/mL warmed (10.95 mM) Water Insoluble |
Appearance | Beige Powder |
Store Temp | 4°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet | |
Brochures |
Hatzivassiliou G, Haling JR, Chen H, et al. Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers. Nature. 2013 Sep 12;501(7466):232-6. PMID: 23934108.
Dihydropyridine, FIASMA; L-type Ca2+ channel bl...
Indirect activator of STING signaling
Nucleotide analog; RT inhibitor.
Analog of rapamycin.
Synthetic ITC, erysolin analog.
CB2 receptor antagonist.
STING inhibitor
Low osmolarity contrast agent used for imaging ...
Epoxomicin analog; proteasome inhibitor.
Toll-like receptor 7/8 agonist
Cytarabine derivative, nucleoside (cytosine) an...
B-Raf, VEGFR2, c-Raf, PDGFR, CSF-1R, RET, c-Kit...
Diterpene found in Anisomeles.
BK/SK, Kv1, Kv3, TASK-2 K+ channel blocker, vol...
p110δ and p110γ PI3K inhibitor.
AMPA positive allosteric modulator, D2, 5-HT2A,...
Mycotoxin that has structural similarity to est...
Histamine H1 antagonist.
Endogenous quaternary ammonium, required for fa...
Peptide, cleavage product of proenkephalin; κO...