Description
Jasplakinolide is a marine toxin that stabilizes actin by inducing polymerization and preventing depolymerization and is used in research models. In animal models, jasplakinolide stimulates follicule growth.
Product Unit Size | Cost | Quantity | Stock |
---|
Jasplakinolide is a marine toxin that stabilizes actin by inducing polymerization and preventing depolymerization and is used in research models. In animal models, jasplakinolide stimulates follicule growth.
Cas No. | 102396-24-7 |
---|---|
Purity | ≥98% |
Formula | C36H45BrN4O6 |
Formula Wt. | 709.68 |
Chemical Name | (4R,7R,10S,13S,15E,17R,19S)-7-[(2-Bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone |
IUPAC Name | (4R,7R,10S,13S,15E,17R,19S)-7-[(2-Bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone |
Synonym | Jaspamide |
Solubility | Soluble in ethanol, methanol or DMSO. |
Appearance | Off-white solid. |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Aida N, Ushikubo T, Kobayashi F, et al. Actin stabilization induces apoptosis in cultured porcine epithelial cell rests of Malassez. Int Endod J. 2015 Jun 27. [Epub ahead of print]. PMID: 26118334.
Cheng Y, Feng Y, Jansson L, et al. Actin polymerization-enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector YAP. FASEB J. 2015 Jun;29(6):2423-30. PMID: 25690654.
Schwingshackl A, Roan E, Teng B, et al. TREK-1 Regulates Cytokine Secretion from Cultured Human Alveolar Epithelial Cells Independently of Cytoskeletal Rearrangements. PLoS One. 2015 May 22;10(5):e0126781. PMID: 26001192.
Alkylphospholipid analog; Akt inhibitor.
Histamine H2 inverse agonist.
RyR agonist, SIRT, telomerase, P2Y, GPCR inhibi...
Antioxidant, vitamin E derivative found in vege...
RT inhibitor.
Bisphosphonate.
Ca2+-sensing receptor agonist.
Nitroimidazole, binds DNA; nucleic acid synthes...
Src and Abl inhibitor.
Loop diuretic; NKCC symporter inhibitor, CFTR C...
pan-PI3K inhibitor
Triazole; 14-α demethylase inhibitor.
ROS1, MET, Ron, Axl, TIE-2, VEGFR2 inhibitor.
Calcium channel blocker.
PORCN inhibitor.
Found in Cladosporium; PKC inhibitor.
D2 and 5-HT2A antagonist.
Retinoid, differentiation inducer.
Endogenous purine nucleotide base, required for...
Platelet substitute, peptide; GP IIb/IIIa activ...