Description
LXH254 is a type II RAF inhibitor.
Product Unit Size | Cost | Quantity | Stock |
---|
LXH254 is a type II RAF inhibitor.
Cas No. | 1800398-38-2 |
---|---|
Purity | ≥99% |
Formula | C25H25F3N4O4 |
Formula Wt. | 502.49 |
IUPAC Name | N-[3-[2-(2-hydroxyethoxy)-6-morpholin-4-ylpyridin-4-yl]-4-methylphenyl]-2-(trifluoromethyl)pyridine-4-carboxamide |
Synonym | Naporafenib |
Appearance | White powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
Info Sheet |
---|
Monaco K, Delach S, Yuan J, et al. LXH254, a potent and selective ARAF-sparing inhibitor of BRAF and CRAF for the treatment of MAPK-driven tumors. Clin Cancer Res. 2021 Apr 1;27(7):2061-2073. PMID: 33355204
Park S, Kim T, Cho S, et al. Combined blockade of polo-like kinase and pan-RAF is effective against NRAS-mutant non-small cell lung cancer cells. Cancer Lett. 2020 Dec 28;495:135-144. PMID: 32979462
Alkaloid found in black and long peppers; TRPV1...
Endogenous peptide hormone, GLP-1 fragment, inv...
Coumarin glucoside found in Aesculus, Daphne, a...
Recombinant BNP, cardiomodulatory peptide; NPR-...
M4 mAChR agonist, 5-HT1A partial agonist, M1/2/...
Triterpene found in Centella, prevents melanoge...
Water-soluble cortisol derivative; glucocortico...
Potential voltage-gated Na+ channel blocker.
Fermentation impurity
Fluoroquinolone; bacterial DNA gyrase inhibitor...
Kavalactone originally found in Piper methystic...
Microtubule polymerization inhibitor.
Found in Capsicum; TRPV agonist.
Synthetic steroid hormone; ER agonist.
AurK, FLT3, Abl inhibitor.
Carnitine derivative, involved in energy homeos...
Isothiocyanate found in cruciferous vegetables....
Diterpene found in brewed, unfiltered coffee; F...
Thalidomide derivative; cereblon and TNF-α inh...
ALK inhibitor.