Paromomycin Sulfate

Name: Paromomycin Sulfate
SKU: P0370
Availability: InStock

Product ID P0370

Cas No. 1263-89-4

Purity ≥98%

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Description

Paromomycin is an aminoglycoside antibiotic that inhibits cation channels such as PX2X receptors; it exhibits antibacterial, anti-parasitic, and anti-protozoal activities. Paromomycin is clinically used to treat leishmaniasis. This compound inhibits ribosomal recycling, binding to the large subunit of the ribosome and inhibiting interactions between the ribosome and ribosome recycling factor (RRF). Paromomycin also decreases the mitochondrial membrane potential and suppresses protein synthesis (inhibiting translocation of RNA).

Product Info

Cas No.	1263-89-4
Purity	≥98%
Formula	C₂₃H₄₅N₅O₁₄ • H₂SO₄
Formula Wt.	713.71
Chemical Name	D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1- >4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1->3)- beta-D-ribofuranosyl-(1->5))-2-deoxy-, sulfate (salt)
IUPAC Name	(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R)-5-[(1R,3S,5R, 6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4, 5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4- hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric acid
Synonym	Aminosidin sulfate, Gabbroral, Aminoxidin, Farmiglucin, Humagel, Humatin, Pargonyl, Sinosid.
Solubility	Soluble in water (>100 mg/mL).

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	P0370 MSDS PDF
Info Sheet	P0370 Info Sheet PDF

References

Bongartz EV, Rettinger J, Hausmann R. Aminoglycoside block of P2X2 receptors heterologously expressed in Xenopus laevis oocytes. Purinergic Signal. 2010 Dec;6(4):393-403. PMID: 21437010.

Jhingran A, Chawla B, Saxena S, et al. Paromomycin: uptake and resistance in Leishmania donovani. Mol Biochem Parasitol. 2009 Apr;164(2):111-7. PMID: 19146886.

Borovinskaya MA, Pai RD, Zhang W, et al. Structural basis for aminoglycoside inhibition of bacterial ribosome recycling. Nat Struct Mol Biol. 2007 Aug;14(8):727-32. PMID: 17660832.