Description
PF-06873600 is a selective inhibitor of CDK2/4/6 in multiple in vivo tumor models.
Product Unit Size | Cost | Quantity | Stock |
---|
PF-06873600 is a selective inhibitor of CDK2/4/6 in multiple in vivo tumor models.
Cas No. | 2185857-97-8 |
---|---|
Purity | ≥98% |
Formula | C20H27F2N5O4S |
Formula Wt. | 471.52 |
IUPAC Name | 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrido[2,3-d]pyrimidin-7-one |
Synonym | PF06873600, Ebvaciclib |
Appearance | White powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
Info Sheet |
---|
Freeman-Cook K, Hoffman R, Miller N, et al. Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor. Cancer Cell. 2021 Oct 11;39(10):1404-1421. PMID: 34520734
Jeselsohn R, Schiff R, Grinshpun A. Restoring order at the cell cycle border: co-targeting CDK4/6 and CDK2. Cancer Cell. 2021 Oct 11;39(10):1302-1305. PMID: 34506738
Freeman-Cook K, Hoffman R, Behenna D, et al. Discovery of PF-06873600, a CDK2/4/6 inhibitor for the treatment of cancer. J Med Chem. 2021 Jul 8;64(13):9056-9077. PMID: 34110834
Synthetic steroid hormone used in HRT; SERM, PR...
Minor kavalactone originally found in Piper met...
Caffeic acid derivative.
Terpene lactone found in Ginkgo; GlyR antagonis...
Mycotoxin produced by species of Fusarium; pote...
Found in Piper longum; TxA2 antagonist, ubiquit...
Pt-based DNA cross-linker.
Precursor in the synthesis of hydroquinone, ant...
SERCA inhibitor.
Diterpenoid found in Rabdosia rubescens; potent...
ROCK inhibitor.
Polyanionic sulfated glycosaminoglycan, encogen...
Cembranoid diterpene found in Sarcophyton glauc...
Penicillin derivative, chelating agent; carboxy...
N-Des-2-methylpropan-2-ol Docetaxel is an impur...
Hec1/Nek2 mitotic pathway inhibitor
Penciclovir prodrug, nucleoside (guanosine) ana...
Nucleoside (deoxyuridine) analog; DNA chain ter...
PI3K and mTOR inhibitor.
Impurity of omeprazole