RFRP-1, human

Name: RFRP-1, human
SKU: R2369
Availability: InStock

Product ID R2369

Cas No.

Purity ≥95%

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Description
Product Info
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References

Description

RFRP-1 is a mammalian ortholog of avian gonadotropin inhibitory hormone (GnIH). RFRP-1 and other RF-amide family peptides activate their own receptor, GPR147. RFRP-1 exhibits anorexigenic, anti-fertility, and anxiogenic activities. RFRP-1-secreting neurons are stress activated and inhibit the secretion of gonadotropin and gonadotropin-releasing hormone (GnRH). In vivo, this peptide inhibits reproductive behavior, decreases food intake, and increases anxiety behavior in an oxytocin-mediated manner.

Product Info

Purity	≥95%
Formula	C₆₇H₁₀₁N₁₉O₁₄S
Formula Wt.	1428.73
Synonym	RF amide-related peptide-1, Neuropeptide VF precursor.
Solubility	Soluble in water.

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	R2369 MSDS PDF
Info Sheet	R2369 Info Sheet PDF

References

Kovács A, László K, Gálosi R, et al. Microinjection of RFRP-1 in the central nucleus of amygdala decreases food intake in the rat. Brain Res Bull. 2012 Sep 1;88(6):589-95. PMID: 22691952.

Kaewwongse M, Takayanagi Y, Onaka T. Effects of RFamide-related peptide (RFRP)-1 and RFRP-3 on oxytocin release and anxiety-related behaviour in rats. J Neuroendocrinol. 2011 Jan;23(1):20-7. PMID: 21029217.

Clarke IJ, Qi Y, Puspita Sari I, et al. Evidence that RF-amide related peptides are inhibitors of reproduction in mammals. Front Neuroendocrinol. 2009 Aug;30(3):371-8. PMID: 19362107.