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SB-202190

Product ID S041001
Cas No. 152121-30-7
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $75.20 In stock
25 mg $227.20 In stock
100 mg $681.50 In stock
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  • Description
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Description

SB-202190 is a highly selective p38 MAPK inhibitor. In a rabbit model, treatment with SB-202190 after filtering glaucoma surgery improved bleb characteristics and intraocular pressure. In a chronic hypoperfusion rat model of vascular dementia, treatment with SB-202190 reduced apoptosis of hippocampal neurons and rescued spatial learning and memory deficits.

Product Info

Cas No.

152121-30-7

Purity

≥99%

Formula

C20H14FN3O

Formula Wt.

331.35

Chemical Name

4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol

IUPAC Name

4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-dihydroimidazol-2-ylidene]cyclohexa-2,5-dien-1-one

Synonym

SB202190; SB 202190; FHPI; UNII-PVX798P8GI ; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole

Solubility

Soluble in DMSO to 100 mM, 20mg/mL in ethanol, 2mg/mL in Ethyl acetate

Appearance

Yellow Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

S041001 MSDS PDF

Info Sheet

S041001 Info Sheet PDF

References

Nassar K, Tura A, Luke J, et al. A p38 MAPK inhibitor improves outcome after glaucoma filtration surgery. J Glaucoma. 2015 Feb;24(2):165-178. PMID: 25493622.

Yang S, Zhou G, Liu H, et al. Protective effects of p38 MAPK inhibitor SB202190 against hippocampal apoptosis and spatial learning and memory deficits in a rat model of vascular dementia. Biomed Red Int. 2013;2013:215798. PMID: 24455679.

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