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Triacsin C

Product ID T6834
Cas No. 76896-80-5
Purity ≥95%
Product Unit SizeCostQuantityStock
0.1 mg $120.00 Please Inquire
0.5 mg $475.00 Please Inquire
1 mg $900.00 In stock
5 mg $3,500.00 Please Inquire
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  • Description
  • Product Info
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  • References
  • Description
  • Product Info
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  • Downloads
  • References
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Description

Triacsin C is a fungal metabolite that acts as a competitive inhibitor of acyl-CoA synthetase, preventing conversion of fatty acids to fatty acyl-CoA. Triacsin C inhibits synthesis of triacylglycerol (TAG), diacylglycerol (DAG), cholesterol esters, and phospholipids. Triacsin C increases NO synthesis and eNOS activity, inducing vasodilatory activity and enhancing relaxation of aortic rings.

Product Info

Cas No.

76896-80-5

Purity

≥95%

Formula

C11H17N3O

Formula Wt.

207.27

IUPAC Name

N-[(E)-[(2E,4E,7E)-undeca-2,4,7-trienylidene]amino]nitrous amide

Melting Point

102-104°C

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

T6834 MSDS PDF

Info Sheet

T6834 Info Sheet PDF

References

Gauthier MS, Miyoshi H, Souza SC, et al. AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance. J Biol Chem. 2008 Jun 13;283(24):16514-24. PMID: 18390901.

Weis MT, Crumley JL, Young LH, et al. Inhibiting long chain fatty Acyl CoA synthetase increases basal and agonist-stimulated NO synthesis in endothelium. Cardiovasc Res. 2004 Aug 1;63(2):338-46. PMID: 15249192.

Igal RA, Wang P, Coleman RA. Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: evidence for functionally separate pools of acyl-CoA. Biochem J. 1997 Jun 1;324 ( Pt 2):529-34. PMID: 9182714.

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