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Vitamin D2

Product ID V3476
Cas No. 50-14-6
Purity ≥91%
Product Unit SizeCostQuantityStock
1 g $46.20 In stock
5 g $166.60 In stock
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  • Product Info
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  • References
  • Description
  • Product Info
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  • Downloads
  • References
  • Custom Order

Description

Calciferol is a Vitamin D prodrug found in fungi and alfalfa; it is commercially used as a vitamin D supplement for bone strength but also exhibits antioxidative and anticancer chemotherapeutic activities. In leukemia cells, calciferol induces apoptosis, decreases the mitochondrial membrane potential, and increases release of cytochrome C, cleavage of PARP, and activation of caspases. In animal models of breast cancer, calciferol decreases tumor growth.

Product Info

Cas No.

50-14-6

Purity

≥91%

Formula

C28H44O

Formula Wt.

396.65

Chemical Name

(3β,5Z,7E,22E)-9,10-Secoergosta-5,7-10(19),22-tetra- en-3-ol

IUPAC Name

(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5, 6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6, 7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol

Synonym

Calciferol, Ergocalciferol, Viosterol, Condol, Deltalin, Diactol, Ergorone, Infron, Mulsiferol, Ostelin, Radsterin

Melting Point

115-118°C

Solubility

Soluble in organic solvents. Insoluble in water.

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

V3476 MSDS PDF

Info Sheet

V3476 Info Sheet PDF

References

Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014 Mar 20;21(3):319-29. PMID: 24529992.

Chen WJ, Huang YT, Wu ML, et al. Induction of apoptosis by vitamin D2, ergocalciferol, via reactive oxygen species generation, glutathione depletion, and caspase activation in human leukemia Cells. J Agric Food Chem. 2008 May 14;56(9):2996-3005. PMID: 18386902.

Zinser GM, Tribble E, Valrance M, et al. 1,24(S)-dihydroxyvitamin D2, an endogenous vitamin D2 metabolite, inhibits growth of breast cancer cells and tumors. Anticancer Res. 2005 Jan-Feb;25(1A):235-41. PMID: 15816543.

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