Description
Y-320 is a phenylpyrazoleanilide that inhibits IL-17 production by CD4+ T cells, preventing the development and progression of arthritis in animal models. This compound displays immunomodulatory and anti-inflammatory activities.
Y-320 is a phenylpyrazoleanilide that inhibits IL-17 production by CD4+ T cells, preventing the development and progression of arthritis in animal models. This compound displays immunomodulatory and anti-inflammatory activities.
Cas No. | 288250-47-5 |
---|---|
Purity | ≥98% |
Formula | C27H29ClN6O2 |
Formula Wt. | 505.02 |
Chemical Name | 1-(4-Chlorophenyl)-N-{3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl}-5-methyl-1H-pyrazole-4-carboxamide |
IUPAC Name | 1-(4-Chlorophenyl)-N-{3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl}-5-methyl-1H-pyrazole-4-carboxamide |
Synonym | Y320 |
Solubility | DMSO 11 mg/mL (21.78 mM) Water Insoluble Ethanol Insoluble |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Ushio H, Ishibuchi S, Oshita K, et al. A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel). 2013 Dec 23;7(1):1-17. PMID: 24366113.
Chiba K. A new orally active anti-rheumatic drug targets IL-15 and IL-17. Nihon Rinsho Meneki Gakkai Kaishi. 2007 Oct;30(5):375-82. PMID: 17984577.
Camptothecin derivative; topoisomerase I inhibi...
5-HT7 and D2/3 antagonist.
Nitrogen mustard, DNA alkylator.
Lck, Src, SIK inhibitor.
Iron chelator.
Dipeptide; aminopeptidase (N/CD13) inhibitor.
Polyphenol found in many plants and foods.
Opioid peptide; μOR agonist.
Found in milk and whey, cation and fatty acid c...
ALK inhibitor.
Metal ion chelator, viral DNA polymerase inhibi...
5-FU prodrug; thymidylate synthase inhibitor.
Minor kavalactone originally found in Piper met...
Endogenous neuropeptide, also known as substanc...
BACE1 inhibitor
FIASMA, mAChR, 5-HT2/3/6/7, α1/2-adrenergic an...
Cyclic hexapeptide isolated from Phomopsis lept...
Semi-synthetic diterpene originally found in Ta...
Xanthine derivative; adenosine antagonist, PDE ...
Found in propolis; 5-lipoxygenase inhibitor.