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4′-Demethylepipodophyllotoxin

4′-Demethylepipodophyllotoxin

Product ID D1849
Cas No. 6559-91-7
Purity ≥98%
Product Unit SizeCostQuantityStock
500 mg $132.00 In stock
1 g $206.00 In stock
5 g $764.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

4’-Demethylepipodophyllotoxin is a topoisomerase II inhibitor found in Podophyllum. Derivatives of this compound exhibit anticancer chemotherapeutic activity.

Product Info

Cas No.

6559-91-7

Purity

≥98%

Formula

C21H20O8

Formula Wt.

400.38

Chemical Name

Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5ah)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5- dimethoxyphenyl)-, (5R-(5-alpha,5a-beta,8a-alpha,9-beta))-

IUPAC Name

(5S,5aR,8aR,9R)-5-hydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a, 9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one

Melting Point

246-248°C

Appearance

White Cystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

D1849 MSDS PDF

Info Sheet

D1849 Info Sheet PDF

References

Xiao L, Zhao W, Li HM, et al. Design and synthesis of the novel DNA topoisomerase II inhibitors: esterification and amination substituted 4'-demethylepipodophyllotoxin derivates exhibiting anti-tumor activity by activating ATM/ATR signaling pathways. Eur J Med Chem. 2014 Jun 10;80:267-77. PMID: 24793877.

Yang TM, Guo SF, Chen CR, et al. Anti-osteosarcoma effects and mechanisms of 4-O-amino-phenol-4'-demethylepipodophyllotoxin ether. J Pharm Pharmacol. 2008 Feb;60(2):179-88. PMID: 18237465.

Custom Order

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  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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