Description
JH-II-127 is a selective inhibitor of leucine-rich repeat kinase 2 (LRRK2), a potential therapeutic target for neurodegenerative disease. It inhibits phosphorylation of Ser910 and Ser935 in both wild-type LRRK2 and the G2019S mutant.
Product Unit Size | Cost | Quantity | Stock |
---|
JH-II-127 is a selective inhibitor of leucine-rich repeat kinase 2 (LRRK2), a potential therapeutic target for neurodegenerative disease. It inhibits phosphorylation of Ser910 and Ser935 in both wild-type LRRK2 and the G2019S mutant.
Cas No. | 1700693-08-8 |
---|---|
Purity | ≥98% |
Formula | C19H21ClN6O3 |
Formula Wt. | 416.87 |
IUPAC Name | (4-{[5-Chloro-4-(methylamino)-3H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-3-methoxyphenyl)(4-morpholinyl)methanone |
Synonym | Pyrrolopyrimidine |
Solubility | DMSO |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Hatcher J., Zhang J., et al. Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett. 6(5):584-9 (2015). PMID: 26005538.
PDK1 inhibitor.
Impurity of rapamycin
MET and Ron inhibitor.
Endogenous opioid peptide; δOR and μOR agonis...
Sartan
Nucleoside (deoxycytidine) analog; DNMT inhibit...
Diterpene found in Rosmarinus.
14-α demethylase inhibitor.
Semi-synthetic derivative of chlorophyll; food ...
principal metabolic product of COX-2
Sterol cell membrane component found in yeast a...
DHF reductase inhibitor.
Diterpene found in Taxus; potential microtubule...
FIASMA, μOR agonist, potential HCN channel blo...
M4 mAChR agonist, 5-HT1A partial agonist, M1/2/...
ROS1, MET, Ron, Axl, TIE-2, VEGFR2 inhibitor.
Macrocyclic lactone.
FK506 analog; calcineurin inhibitor.
Integrase inhibitor.
Side chain commonly attached to taxanes.