• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Parthenolide

Parthenolide

Product ID P0270
Cas No. 20554-84-1
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $78.80 Please Inquire
100 mg $157.50 Please Inquire
250 mg $315.00 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Parthenolide is a sesquiterpene lactone found in Tanacetum that exhibits anticancer chemotherapeutic, anti-metastatic, anti-angiogenic, anti-inflammatory, and antinociceptive activities. Parthenolide acts as a partial agonist at transient receptor potential ankyrin 1 (TRPA1) channels and desensitizes them, preventing release of calcitonin gene-related peptide (CGRP). Additionally, parthenolide inhibits ATPase activity of NLRP3 and protease activity of caspase 1. In multiple myeloma cells, parthenolide decreases expression of NF-κB, VEGF, and IL-6 and increases expression of IκB kinase, inhibiting cell migration and tubule formation. In non-small cell lung cancer (NSCLC) cells, parthenolide decreases levels of MCL-1 and increases levels of MAIP-1, triggering ER stress and inducing cell cycle arrest and apoptosis. In breast cancer cells, this compound activates NADPH oxidase and increases ROS generation, increasing levels of p-JNK and downregulating NF-κB, VEGF, and matrix metalloproteinases 2 and 9 (MMP2/9); in vivo, parthenolide inhibits tumor growth and metastasis.

Product Info

Cas No.

20554-84-1

Purity

≥98%

Formula

C15H20O3

Formula Wt.

248.32

IUPAC Name

(1S,2R,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one

Melting Point

112-115°C

Solubility

DMSO (100 mg/ml), Ethanol (20 mg/ml), Dichloromethane.

Appearance

White Crystals

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

P0270 MSDS PDF

Info Sheet

P0270 Info Sheet PDF

Brochures

TRP Channel Modulator Flyer

References

Zhao X, Liu X, Su L. Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells. J Exp Clin Cancer Res. 2014 Jan 6;33(1):3. PMID: 24387758.

Materazzi S, Benemei S, Fusi C, et al. Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel. Pain. 2013 Dec;154(12):2750-8. PMID: 23933184.

D'Anneo A, Carlisi D, Lauricella M, et al. Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer. Cell Death Dis. 2013 Oct 31;4:e891. PMID: 24176849.

Juliana C, Fernandes-Alnemri T, Wu J, et al. Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J Biol Chem. 2010 Mar 26;285(13):9792-802. PMID: 20093358.

https://en.wikipedia.org/wiki/Parthenolide

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C1668

    Cerivastatin Sodium

    Statin; HMG-CoA reductase inhibitor.

    ≥98%
  • A6268

    Aprotinin

    Polypeptide; serine protease inhibitor.

    ≥ 5400 u/mg
  • S3368

    S1RA

    σ1 antagonist.

    ≥99%
  • S3470

    Sirtinol

    Sirtuin inhibitor and iron chelator.

    ≥98%
  • C022682

    2-Carbomethoxy-3-thiophenesulfonyl Chloride

    Building block

    ≥98%
  • I0902

    Icaritin

    Flavonoid found in Epimedium.

    ≥98%
  • V0252

    Vancomycin Hydrochloride

    Glycopeptide, binds D-Ala-D-Ala; cell wall synt...

    ≥1050 IU/mg, bio assay
  • P200002

    PF-07321332

    Inhibitor of coronaviruses

    ≥99%
  • P3597

    Pizotyline Malate

    5-HT1A partial agonist, 5-HT2C antagonist.

    ≥98%
  • B6802

    Bradykinin (1-3)

    Natriuretic, vasodilatory peptide fragment; B1/...

    ≥95%
  • F4581

    5-Fluorocytosine

    Synthetic antifungal.

    ≥98%
  • K0032

    Kahweol Palmitate

    Diterpene found in coffee beans.

    ≥97%
  • G3359

    Ginkgolide J

    Terpene lactone found in Ginkgo.

    ≥98%
  • V014457

    Valnemulin Hydrochloride

    Pleuromutilin

    ≥98%
  • A6970

    Artemether

    Sesquiterpene lactone derived from Artemesia.

    ≥98%
  • D5897

    Doxycycline Hyclate

    Tetracycline; protein translation inhibitor, MM...

    ≥97%
  • N1978

    Neurokinin B

    Neuromodulator, biomarker

    ≥95%
  • X4424

    XL-765

    PI3K and mTOR inhibitor.

    ≥98%
  • L0076

    Latrunculin A

    Thiazolidine macrolide found in the Red Sea spo...

  • A0248

    BAM-12P

    Peptide, cleavage product of proenkephalin; κO...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only