• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Parthenolide

Parthenolide

Product ID P0270
Cas No. 20554-84-1
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $78.80 Please Inquire
100 mg $157.50 Please Inquire
250 mg $315.00 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Parthenolide is a sesquiterpene lactone found in Tanacetum that exhibits anticancer chemotherapeutic, anti-metastatic, anti-angiogenic, anti-inflammatory, and antinociceptive activities. Parthenolide acts as a partial agonist at transient receptor potential ankyrin 1 (TRPA1) channels and desensitizes them, preventing release of calcitonin gene-related peptide (CGRP). Additionally, parthenolide inhibits ATPase activity of NLRP3 and protease activity of caspase 1. In multiple myeloma cells, parthenolide decreases expression of NF-κB, VEGF, and IL-6 and increases expression of IκB kinase, inhibiting cell migration and tubule formation. In non-small cell lung cancer (NSCLC) cells, parthenolide decreases levels of MCL-1 and increases levels of MAIP-1, triggering ER stress and inducing cell cycle arrest and apoptosis. In breast cancer cells, this compound activates NADPH oxidase and increases ROS generation, increasing levels of p-JNK and downregulating NF-κB, VEGF, and matrix metalloproteinases 2 and 9 (MMP2/9); in vivo, parthenolide inhibits tumor growth and metastasis.

Product Info

Cas No.

20554-84-1

Purity

≥98%

Formula

C15H20O3

Formula Wt.

248.32

IUPAC Name

(1S,2R,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one

Melting Point

112-115°C

Solubility

DMSO (100 mg/ml), Ethanol (20 mg/ml), Dichloromethane.

Appearance

White Crystals

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

P0270 MSDS PDF

Info Sheet

P0270 Info Sheet PDF

Brochures

TRP Channel Modulator Flyer

References

Zhao X, Liu X, Su L. Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells. J Exp Clin Cancer Res. 2014 Jan 6;33(1):3. PMID: 24387758.

Materazzi S, Benemei S, Fusi C, et al. Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel. Pain. 2013 Dec;154(12):2750-8. PMID: 23933184.

D'Anneo A, Carlisi D, Lauricella M, et al. Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer. Cell Death Dis. 2013 Oct 31;4:e891. PMID: 24176849.

Juliana C, Fernandes-Alnemri T, Wu J, et al. Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J Biol Chem. 2010 Mar 26;285(13):9792-802. PMID: 20093358.

https://en.wikipedia.org/wiki/Parthenolide

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M324081

    Micafungin Sodium

    Echinocandin antifungal

    ≥98%
  • M9368

    Myristicin

    Allylbenzene found in spices and umbelliferous ...

    ≥98%
  • M3476

    Mithramycin

    Polyketide; DNMT 1 inhibitor, RNA synthesis inh...

    ≥98%
  • T6811

    Tranexamic Acid

    Plasminogen inhibitor.

    ≥98%
  • M568268

    Mogroside IV

    Triterpenoid

    ≥98%
  • E4418

    β-Elemene

    Sesquiterpene found in various plant sources. <...

    ≥98%
  • T3036

    Thienylhexyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥97%
  • B6801

    Brassinin

    Phytoalexin, indole found in cruciferous vegeta...

    ≥98%
  • W0247

    Walrycin B

    Walrycin response regulator inhibitor.

    ≥98%
  • V014451

    Valiltramiprosate

    beta-Amyloid anti-oligomer and aggregation inhi...

    ≥99%
  • B3278

    Biotin

    Water-soluble coenzyme, vitamin (B7) found in v...

    ≥98%
  • A7656

    Atomoxetine Hydrochloride

    NET and SERT inhibitor, NMDA antagonist.

    ≥99%
  • M0114

    Madecassic Acid

    Downregulates LPS-stimulated expression of pro-...

    ≥95%
  • B3458

    Biopterin

    Endogenous pterin coenzyme required for release...

    ≥98%
  • C2965

    Chromium Picolinate

    Used to prevent chromium deficiency and to decr...

    ≥98%
  • S760004

    Stachybotrylactam

    Spirodihydrobenzofuranlactam

    ≥98%
  • S3568

    Siramesine

    σ2 agonist.

    ≥98%
  • B0396

    BAY80-6946

    p110α PI3K inhibitor.

    ≥98%
  • Z1216

    Z-DEVD-AMC

    Caspase substrate.
    ≥95%
  • O5212

    Ondansetron Hydrochloride Dihydrate

    5-HT3 antagonist.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only