• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Neuroscience
    • Endocrine Signaling and Immunology
    • Cardiovascular
    • Microbiology
    • Metabolic and GI Pathology
    • Natural Products
    • Peptides
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register

Sarafotoxin 6c

Product ID S0171
Cas No. 121695-87-2
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $278.30 Please Inquire
1 mg $493.50 Please Inquire
2.5 mg $992.30 Please Inquire
Bulk Quote
Add to Wishlist

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Sarafotoxin 6C (S6C) is an isoform of a toxin found in the venom of Atractaspis engaddensis snakes. S6C acts as a peptide agonist at endothelin B (ET-B) receptors and exhibits anti-arrhythmic and cardiomodulatory activities. S6C can be vasodilatory, vasoconstrictive, cardiotoxic, or cardioprotective depending on the model being studied. When administered as a pretreatment prior to cerebral occlusion in animal models of cardiac ischemia/reperfusion, S6C induces NO release and activates mitoK(ATP) K+ channels, decreasing infarct size and arrhythmia occurrence and increasing overall survival rates. S6C also increases levels of superoxide anions in sympathetic ganglia and induces hypertension in some animal models. In vitro, S6C delays suicidal erythrocyte death, and in contracted aortic and vena cava rings, it induces relaxation.

Product Info

Cas No.

121695-87-2

Purity

≥95%

Formula

C103H147N27O37S5

Formula Wt.

2515.8

Synonym

SRTX-c, Sarfotoxin S6c

Solubility

Soluble in 5% acetic acid, water (1 mg/mL).

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S0171 MSDS PDF

Info Sheet

S0171 Info Sheet PDF

References

Li J, Cao YX, Liu Y, et al. Minimally modified LDL upregulates endothelin type B receptors in rat basilar artery. Microvasc Res. 2012 Mar;83(2):178-84. PMID: 22198335.

Föller M, Mahmud H, Qadri SM, et al. Endothelin B receptor stimulation inhibits suicidal erythrocyte death. FASEB J. 2010 Sep;24(9):3351-9. PMID: 20427706.

Tykocki NR, Gariepy CE, Watts SW. Endothelin ET(B) receptors in arteries and veins: multiple actions in the vein. J Pharmacol Exp Ther. 2009 Jun;329(3):875-81. PMID: 19297422.

Li M, Dai X, Watts S, et al. Increased superoxide levels in ganglia and sympathoexcitation are involved in sarafotoxin 6c-induced hypertension. Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1546-54. PMID: 18768769.

Das B, Sarkar C, Shankar PR. Pretreatment with sarafotoxin 6c prior to coronary occlusion protects against infarction and arrhythmias via cardiomyocyte mitochondrial K(ATP) channel activation in the intact rabbit heart during ischemia/reperfusion. Cardiovasc Drugs Ther. 2007 Aug;21(4):243-51. PMID: 17520332.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2021 LKT Laboratories, All Rights Reserved - Products for research use only