Description
SR144528 is a selective CB2 antagonist. It is used to study the role of cannabinoid receptor 2 in immunology, neuroscience and cancer. Recent research shows SR144528 to reduce immunoglobulin human SKW 6.4 cells.
SR144528
Product ID S680000
Cas No. 192703-06-3
Purity ≥98%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 192703-06-3 |
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| Purity | ≥98% |
| Formula | C29H34ClIN3O |
| Formula Wt. | 476.06 |
| Chemical Name | 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1R,3S,4S)-2,2,4-trimethyl-3-bicyclo[2.2.1]heptanyl]pyrazole-3-carboxamide |
| IUPAC Name | 5-(4-Chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrazole-3-carboxamide |
| Solubility | Soluble in ethanol (~20 mg/ml), DMSO (~20 mg/ml), DMF (~20 mg/ml), and 1: 1 ethanol: PBS (pH 7.2) (~0.5 mg/ml). |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Feng R, Milcarek CA, Xie XQ. Antagonism of cannabinoid receptor 2 pathway suppresses IL-6-induced immunoglobulin IgM secretion. BMC Pharmacol Toxicol. 2014 Jun 9;15:30. PMID: 24913620.
Krylatov AV, Maslov LN, Lasukova OV and Pertwee RG. Cannabinoid receptor antagonists SR141716 and SR144528 exhibit properties of partial agonists in experiments on isolated perfused rat heart. Bull Exp Biol Med. 2005 May;139(5):558-61. PMID: 16224548.