LKT Labs

Biochemicals for Life Science Research

Panaxatriol

Panaxatriol

Product ID P0254
Cas No. 32791-84-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $114.00 Please Inquire
5 mg $225.00 In stock
10 mg $375.00 In stock
25 mg $575.00 In stock
Bulk Quote

Quicklinks

Description

Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) that exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities. Panaxatriol increases expression of heme oxygenase 1 (HO-1) and activation of Nrf2 signaling in neurons in a PI3K/Akt-dependent manner. Panaxatriol also decreases acetaminophen-induced increases in ALT and TNF-α, preventing liver injury in vivo. Additionally, panaxatriol inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.

Product Info

Cas No.

32791-84-7
Purity

≥98%
Formula

C30H52O4
Formula Wt.

476.73
IUPAC Name

(3S,5R,6R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2, 6,6-trimethyloxan-2-yl]-2,3,5,6,7,9,11,12,13,15,16, 17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol
Melting Point

238-239C
Solubility

Soluble in DMSO.
Appearance

White Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P0254 MSDS PDF
Info Sheet

P0254 Info Sheet PDF

References

Huang Y, Yu J, Wan F, et al. Panaxatriol Saponins Attenuated Oxygen-Glucose Deprivation Injury in PC12 Cells via Activation of PI3K/Akt and Nrf2 Signaling Pathway. Oxid Med Cell Longev. 2014;2014:978034. PMID: 24955212.

Wang S, Wang X, Luo F, et al. Panaxatriol saponin ameliorated liver injury by acetaminophen via restoring thioredoxin-1 and pro-caspase-12. Liver Int. 2013 Sep 11. [Epub ahead of print]. PMID: 24119161.

Zhang WJ, Zhong GG, Jiang Y, et al. Single channel analysis on calcium channel blockade action of panaxadiol and panaxatriol saponins on cultured rat ventricular myocytes. Zhongguo Yao Li Xue Bao. 1994 Mar;15(2):173-6. PMID: 7516611.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P1200

    PD-184352

    MEK1/2 and Raf inhibitor.

    ≥98%
  • L9800

    LY-364947

    ALK5 (activin-like) inhibitor.

    ≥98%
  • L5750

    Lomeguatrib

    MGMT inhibitor.

    ≥98%
  • B6806

    Bradykinin (2-9)

    Natriuretic, vasodilatory peptide fragment; B1/...

    ≥95%
  • P2816

    S-(N-3-Phenylpropylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate.

    ≥98%
  • O4104

    Okadaic Acid Sodium

    Shellfish toxin produced by dinoflagellates and...

    ≥98%
  • J974440

    JZL184

    MAGL inhibitor.

    ≥98%
  • F6803

    FRAX486

    PAK inhibitor.Smo inhibitor.

    ≥98%
  • P1760

    Peptide T

    Peptide fragment of HIV-1 gp120.

    ≥98%
  • P7082

    Prulifloxacin

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • P3313

    Pidotimod

    Immunostimulator, adjuvant.

    ≥98%
  • C9608

    Cycloastragenol

    Triterpene aglycone found in Radix Astragali; t...

    ≥98%
  • C1876

    Cetirizine Dihydrochloride

    Histamine H1 antagonist.

    ≥99%
  • P5845

    Polydatin

    Stilbenoid glucoside found in Polygonum.

    ≥97%
  • M1560

    Methyl Caffeate

    Polyphenol found in species of Solanum and Magn...

    ≥98%
  • L8261

    Lupeol

    Triterpene; potential tyrosinase inhibitor.

    ≥98%
  • F5968

    Foretinib

    ROS1, MET, Ron, Axl, TIE-2, VEGFR2 inhibitor.

    ≥98%
  • G1721

    Gefitinib

    EGFR inhibitor.

    ≥98%
  • T165131

    Tedizolid

    Effective against gram-positive pathogens

    ≥98%
  • O6932

    Oridonin

    Diterpenoid found in Rabdosia rubescens; potent...

    ≥98%