LKT Labs

Biochemicals for Life Science Research

Panaxatriol

Panaxatriol

Product ID P0254
Cas No. 32791-84-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $114.00 Please Inquire
5 mg $225.00 In stock
10 mg $375.00 In stock
25 mg $575.00 In stock
Bulk Quote

Quicklinks

Description

Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) that exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities. Panaxatriol increases expression of heme oxygenase 1 (HO-1) and activation of Nrf2 signaling in neurons in a PI3K/Akt-dependent manner. Panaxatriol also decreases acetaminophen-induced increases in ALT and TNF-α, preventing liver injury in vivo. Additionally, panaxatriol inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.

Product Info

Cas No.

32791-84-7
Purity

≥98%
Formula

C30H52O4
Formula Wt.

476.73
IUPAC Name

(3S,5R,6R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2, 6,6-trimethyloxan-2-yl]-2,3,5,6,7,9,11,12,13,15,16, 17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol
Melting Point

238-239C
Solubility

Soluble in DMSO.
Appearance

White Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P0254 MSDS PDF
Info Sheet

P0254 Info Sheet PDF

References

Huang Y, Yu J, Wan F, et al. Panaxatriol Saponins Attenuated Oxygen-Glucose Deprivation Injury in PC12 Cells via Activation of PI3K/Akt and Nrf2 Signaling Pathway. Oxid Med Cell Longev. 2014;2014:978034. PMID: 24955212.

Wang S, Wang X, Luo F, et al. Panaxatriol saponin ameliorated liver injury by acetaminophen via restoring thioredoxin-1 and pro-caspase-12. Liver Int. 2013 Sep 11. [Epub ahead of print]. PMID: 24119161.

Zhang WJ, Zhong GG, Jiang Y, et al. Single channel analysis on calcium channel blockade action of panaxadiol and panaxatriol saponins on cultured rat ventricular myocytes. Zhongguo Yao Li Xue Bao. 1994 Mar;15(2):173-6. PMID: 7516611.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • Z160021

    Zearalanone

    Mycotoxin.

    ≥97%
  • Z1602

    Zearalenone

    Mycotoxin produced by Fusarium; ER agonist.

    ≥98%
  • T3098

    Thymosin β-4 Acetate

    Endogenous peptide; actin polymerization inhibi...

    ≥95%
  • O5212

    Ondansetron Hydrochloride Dihydrate

    5-HT3 antagonist.

    ≥98%
  • B8278

    Butoconazole Nitrate

    Imidazole; 14-α demethylase inhibitor.

    ≥98%
  • G124082

    GDC-0941

    pan-PI3K inhibitor.

    ≥98%
  • S3584

    Sivelestat Sodium Tetrahydrate

    Neutrophil elastase inhibitor.

    ≥99%
  • P2522

    S-(N-Phenylthiocarbamoyl)-glutathione

    Glutathione-ITC conjugate, antioxidant.

    ≥98%
  • B3278

    Biotin

    Water-soluble coenzyme, vitamin (B7) found in v...

    ≥98%
  • B8276

    Butyric Acid Sodium

    HDAC inhibitor, RNA splicing modulator.

    ≥98%
  • U6801

    Urapidil

    5-HT1A agonist, α1-adrenergic antagonist.

    ≥98%
  • F4583

    Flupirtine Maleate

    Kv7 K+ channel activator, NMDA antagonist, GABA...

    ≥98%
  • C2949

    Chlorpheniramine Maleate

    Alkylamine; histamine H1 antagonist, SERT and N...

    ≥98%
  • T3196

    Thymoquinone

    Phytochemical from Nigella sativa.

    ≥98%
  • E9201

    EX-527

    SIRT1 inhibitor.

    ≥99%
  • D0244

    Dalcetrapib

    Cholesterol ester transfer protein inhibitor.

    ≥98%
  • P2410

    Phenethyl Dimethyl Caffeate

    Caffeic acid derivative.

    ≥98%
  • H5654

    Honokiol

    Lignan found in species of Magnolia; GABA-A pot...

    ≥99%
  • P3561

    Piperlongumine

    Found in Piper longum; TxA2 antagonist, ubiquit...

    ≥98%
  • L9704

    LY-2603618

    Chk1 inhibitor.

    ≥98%