LKT Labs

Biochemicals for Life Science Research

Panaxatriol

Panaxatriol

Product ID P0254
Cas No. 32791-84-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $114.00 Please Inquire
5 mg $225.00 In stock
10 mg $375.00 In stock
25 mg $575.00 In stock
Bulk Quote

Quicklinks

Description

Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) that exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities. Panaxatriol increases expression of heme oxygenase 1 (HO-1) and activation of Nrf2 signaling in neurons in a PI3K/Akt-dependent manner. Panaxatriol also decreases acetaminophen-induced increases in ALT and TNF-α, preventing liver injury in vivo. Additionally, panaxatriol inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.

Product Info

Cas No.

32791-84-7
Purity

≥98%
Formula

C30H52O4
Formula Wt.

476.73
IUPAC Name

(3S,5R,6R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2, 6,6-trimethyloxan-2-yl]-2,3,5,6,7,9,11,12,13,15,16, 17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol
Melting Point

238-239C
Solubility

Soluble in DMSO.
Appearance

White Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P0254 MSDS PDF
Info Sheet

P0254 Info Sheet PDF

References

Huang Y, Yu J, Wan F, et al. Panaxatriol Saponins Attenuated Oxygen-Glucose Deprivation Injury in PC12 Cells via Activation of PI3K/Akt and Nrf2 Signaling Pathway. Oxid Med Cell Longev. 2014;2014:978034. PMID: 24955212.

Wang S, Wang X, Luo F, et al. Panaxatriol saponin ameliorated liver injury by acetaminophen via restoring thioredoxin-1 and pro-caspase-12. Liver Int. 2013 Sep 11. [Epub ahead of print]. PMID: 24119161.

Zhang WJ, Zhong GG, Jiang Y, et al. Single channel analysis on calcium channel blockade action of panaxadiol and panaxatriol saponins on cultured rat ventricular myocytes. Zhongguo Yao Li Xue Bao. 1994 Mar;15(2):173-6. PMID: 7516611.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A225822

    Afuresertib

    Inhibitor of Akt.

    ≥98%
  • T1854

    Tenofovir Monohydrate

    Nucleotide analog; RT inhibitor.

    ≥98%
  • R1985

    Reveromycin A

    Isoleucyl-tRNA synthase inhibitor, osteoclast p...

    ≥98%
  • L943721

    LXS-196

    Selective inhibitor of protein kinase C (PKC).<...

    ≥98%
  • L589921

    Loxapine Succinate

    D2 and D4 dopamine receptor inhibitor.

    ≥99%
  • Q8134

    Quinapril Hydrochloride

    ACE inhibitor.

    ≥98%
  • T0393

    (+/-)-Taxifolin Hydrate

    Catechol-type flavonoid.

    ≥95%
  • N4972

    NMS-873

    Valosin-containing protein inhibitor.

    ≥98%
  • E4416

    Eledoisin

    Peptide, substance P analog; NK agonist.

    ≥95%
  • A7618

    Atenolol

    β1-adrenergic antagonist.

    ≥98%
  • A5278

    Angiotensin III, human

    Endogenous peptide, cleavage product of AT II; ...

    ≥95%
  • X1854

    p-Xyleneselenocyanate

    Synthetic derivative of selenocyanate.

    ≥99%
  • H9613

    N-(4-Hydroxyphenyl)retinamide

    Retinol (vitamin A) analog, binds RBP4; Des1 in...

    ≥98%
  • I538583

    Inosine

    Adenosine analog

    ≥98%
  • U0618

    Ubenimex

    Dipeptide; aminopeptidase (N/CD13) inhibitor.

    ≥98%
  • C0396

    CAY10505

    p110γ PI3K inhibitor.

    ≥98%
  • G1200

    GDC-0068

    Akt inhibitor.

    ≥98%
  • S3476

    Sitagliptin Phosphate Monohydrate

    DPP4 inhibitor.

    ≥98%
  • C9863

    Cyproconazole

    Triazole; 14-α demethylase inhibitor, voltage-...

    ≥95%
  • F334453

    Filipin III

    Antifungal antibiotic

    ≥95%