LKT Labs

Biochemicals for Life Science Research

Panaxatriol

Product ID P0254
Cas No. 32791-84-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $108.80 Please Inquire
5 mg $262.00 In stock
10 mg $454.90 In stock
25 mg $909.20 In stock
Bulk Quote

Quicklinks

Description

Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) that exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities. Panaxatriol increases expression of heme oxygenase 1 (HO-1) and activation of Nrf2 signaling in neurons in a PI3K/Akt-dependent manner. Panaxatriol also decreases acetaminophen-induced increases in ALT and TNF-α, preventing liver injury in vivo. Additionally, panaxatriol inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.

Product Info

Cas No.

32791-84-7
Purity

≥98%
Formula

C30H52O4
Formula Wt.

476.73
IUPAC Name

(3S,5R,6R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2, 6,6-trimethyloxan-2-yl]-2,3,5,6,7,9,11,12,13,15,16, 17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol
Melting Point

238-239C
Solubility

Soluble in DMSO.
Appearance

White Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P0254 MSDS PDF
Info Sheet

P0254 Info Sheet PDF

References

Huang Y, Yu J, Wan F, et al. Panaxatriol Saponins Attenuated Oxygen-Glucose Deprivation Injury in PC12 Cells via Activation of PI3K/Akt and Nrf2 Signaling Pathway. Oxid Med Cell Longev. 2014;2014:978034. PMID: 24955212.

Wang S, Wang X, Luo F, et al. Panaxatriol saponin ameliorated liver injury by acetaminophen via restoring thioredoxin-1 and pro-caspase-12. Liver Int. 2013 Sep 11. [Epub ahead of print]. PMID: 24119161.

Zhang WJ, Zhong GG, Jiang Y, et al. Single channel analysis on calcium channel blockade action of panaxadiol and panaxatriol saponins on cultured rat ventricular myocytes. Zhongguo Yao Li Xue Bao. 1994 Mar;15(2):173-6. PMID: 7516611.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • K0030

    Kahweol

    Diterpene found in coffee beans.

    ≥97%
  • F4681

    Flumazenil

    GABA-A antagonist.

    ≥98%
  • A7476

    Astaxanthin

    Carotenoid found in shrimp, salmon, and algae.<...

    ≥97%
  • D490280

    DMH-1

    Inhibitor of BMP.

    ≥99%
  • C4517

    Clenbuterol Hydrochloride

    β2-adrenergic agonist.

    ≥98%
  • G2868

    Ghrelin, human

    Endogenous peptide hormone, involved in feeding...

    ≥98%
  • G5322

    GNF-5

    Abl inhibitor.

    ≥99%
  • G124082

    GDC-0941

    pan-PI3K inhibitor.

    ≥98%
  • A4675

    Alternariol

    Mycotoxin produced by Alternaria; topoisomerase...

    ≥98%
  • E8419

    Everolimus

    mTORC1 inhibitor.

    ≥98%
  • G1975

    Gestrinone

    Synthetic steroid hormone; AR agonist, ER and P...

    ≥98%
  • B0396

    BAY80-6946

    p110α PI3K inhibitor.

    ≥98%
  • A8812

    AWD 131-138

    GABA-A positive modulator.

    ≥99%
  • C691325

    Cridanimod

    STING agonist

    ≥99%
  • C9614

    Cyclosporin H

    Cyclosporin metabolite; formyl peptide inhibito...

    ≥96%
  • S3453

    Sinigrin Monohydrate, synthetic

    ITC precursor found in cruciferous vegetables.<...

    ≥98%
  • H9711

    (Z)-4-Hydroxytamoxifen

    SERM.

    ≥98%
  • M400220

    MK-2206 Dihydrochloride

    Akt inhibitor.

    ≥99%
  • G124090

    GDC-6036

    KRAS inhibitor

    ≥98%
  • C2845

    Levo-Chloramphenicol

    Protein translation inhibitor, peptidyl transfe...

    ≥98%