Cryptotanshinone

Name: Cryptotanshinone
SKU: C7097
Availability: InStock

Product ID C7097

Cas No. 35825-57-1

Purity ≥90%

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Description
Product Info
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References

Description

Cryptotanshinone is a quinoid diterpene found in species of Salvia that exhibits anticancer and anti-angiogenic activities. Cryptotanshinone directly inhibits dimerization of STAT3, disrupting STAT3 activation and signaling and inhibiting proliferation in glioma cells. This compound also induces G1/G0 phase cell cycle arrest and inhibits activation of mTOR, p70S6K, and eIF4eBP in rhabdomyosarcoma cells. Additionally, cryptotanshinone downregulates expression of VEGF and inhibits HIF-1α signaling, disturbing tube formation in vitro.

Product Info

Cas No.	35825-57-1
Purity	≥90%
Formula	C₁₉H₂₀O₃
Formula Wt.	296.36
IUPAC Name	(1R)-1,6,6-trimethyl-2,7,8,9-tetrahydro-1H-naphtho[1, 2-g][1]benzofuran-10,11-dione
Melting Point	184-185°C
Solubility	Soluble in chloroform, methanol
Appearance	Red Crystal Powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	C7097 MSDS PDF
Info Sheet	C7097 Info Sheet PDF
Brochures	JAK/STAT Flyer

References

Lu L, Li C, Li D, et al. Cryptotanshinone inhibits human glioma cell proliferation by suppressing STAT3 signaling. Mol Cell Biochem. 2013 Sep;381(1-2):273-82. PMID: 23740516.

Lee HJ, Jung DB, Sohn EJ, et al. Inhibition of Hypoxia Inducible Factor Alpha and Astrocyte-Elevated Gene-1 Mediates Cryptotanshinone Exerted Antitumor Activity in Hypoxic PC-3 Cells. Evid Based Complement Alternat Med. 2012;2012:390957. rratum in: Evid Based Complement Alternat Med. 2013;2013:267352. PMID: 23243443.

Chen W, Luo Y, Liu L, et al. Cryptotanshinone inhibits cancer cell proliferation by suppressing Mammalian target of rapamycin-mediated cyclin D1 expression and Rb phosphorylation. Cancer Prev Res (Phila). 2010 Aug;3(8):1015-25. PMID: 20628002.

Shin DS, Kim HN, Shin KD, et al. Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res. 2009 Jan 1;69(1):193-202. PMID: 19118003.

Li W, Li J, Ashok M, et al. A cardiovascular drug rescues mice from lethal sepsis by selectively attentuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol. 2007 Mar 15;178(6):3856-3864. PMID: 17339485.

Zhang Y, Won SH, Jiang C, et al. Tanshinones fmor Chinese medicinal herb Danshen (Salvia miltiorrhiza Bunge) suppress prostate cancer growth and androgen receptor signaling. Pharm Res. 2012 Jun;29(6):1595-1608. PMID: 22281759.