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Ganciclovir is a guanosine nucleoside analog that exhibits antiviral activity. Ganciclovir is clinically used to treat cytomegalovirus infection; it inhibits viral DNA polymerase and acts as a chain terminator when incorporated into DNA, limiting DNA synthesis. Ganciclovir is often co-administered with HSV thymidine kinase gene therapy as a sensitizer.
| Cas No. | 82410-32-0 |
|---|---|
| Purity | ≥98% |
| Formula | C9H13N5O4 |
| Formula Wt. | 255.23 |
| Chemical Name | 2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]- methyl]-6H-purin-6-one |
| IUPAC Name | 2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one |
| Synonym | DHPG, 2'NDG, BIOLF |
| Melting Point | 250°C (dec) |
| Solubility | Soluble in water (2 mg/mL), 0.1 M HCl (10 mg/mL), DMSO (5 mg/mL), ethanol (<1 mg/mL). |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Prichard MN, Kern ER. The search for new therapies for human cytomegalovirus infections. Virus Res. 2011 May;157(2):212-21. PMID: 21095209.
Abate-Daga D, Garcia-Rodríguez L, Sumoy L, et al. Cell cycle control pathways act as conditioning factors for TK/GCV sensitivity in pancreatic cancer cells. Biochim Biophys Acta. 2010 Oct;1803(10):1175-85. PMID: 20599444.
De Clercq E, Neyts J. Antiviral agents acting as DNA or RNA chain terminators. Handb Exp Pharmacol. 2009;(189):53-84. PMID: 19048197.
