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Heparin Sodium

Product ID H1658
Cas No. 9041-08-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $136.70 In stock
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  • Product Info
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  • References
  • Description
  • Product Info
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  • Custom Order

Description

Heparin is an endogenous glycosaminoglycan that is produced by mast cells and basophils and exhibits a negative charge. Heparin displays anticoagulant activity. Heparin binds antithrombin III, activating the protein and inhibiting binding and activation of thrombin and Factor Xa. In vivo, heparin may inhibit the formation of bone and cartilage. Heparin is also a natural ligand for anaplastic lymphoma kinase (ALK), an oncogenic kinase involved in anaplastic large-cell lymphomas.

Product Info

Cas No.

9041-08-1

Purity

≥98%

Formula Wt.

4,000-6,000 Da

IUPAC Name

(4S,6R)-6-[(2R,4R)-4,6-dihydroxy-5-(sulfonatoamino)-2-(sulfonatooxymethyl)oxan-3-yl]oxy-3,4-dihydroxy-5-sulfonatooxyoxane-2-carboxylate

Synonym

Heparin sodium salt, Heprinar, Hepsal, Monoparin, Panheprin, Liquaemin Sodium, Minihep, Thrombophob, Unihep

Solubility

Soluble in water (50mg/mL) and saline solutions. Practically insoluble in alcohol, acetone, benzene, chloroform or ether. DMSO <1 mg/mL

Appearance

White or almost white amorphous powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

H1658 MSDS PDF

Info Sheet

H1658 Info Sheet PDF

References

Murray PB, Lax I, Reshetnyak A, et al. Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK. Sci Signal. 2015 Jan 20;8(360):ra6. PMID: 25605972.

Brkljacic J, Pauk M, Erjavec I, et al. Exogenous heparin binds and inhibits bone morphogenetic protein 6 biological activity. Int Orthop. 2013 Mar;37(3):529-41. PMID: 23307015.

Chuang YJ, Swanson R, Raja SM, et al. Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin. J Biol Chem. 2001 May 4;276(18):14961-71. PMID: 11278930.

Yokoyama T, Takeuchi A, Yamamoto M, et al. Heparin enhances the cell-protein misfolding cyclic amplification efficiency of variant Creutzfeldt-Jakob disease. Neurosci Lett. 2011 Jul 8;498(2):119-123. PMID: 21565253.

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