LKT Labs

Biochemicals for Life Science Research

R-Bicalutamide

Product ID B3210
Cas No. 113299-40-4
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $102.10 In stock
100 mg $229.00 In stock
250 mg $415.10 In stock
1 g $1,226.60 In stock
Bulk Quote

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Description

R-Bicalutimide is an inhibitor of the androgen receptor that exhibits anticancer chemotherapeutic activity. With other anti-androgens, R-bicalutimide decreases levels of Bcl-2, Bcl-XL, caspase-3, and PARP, induces apoptosis, and inhibits cell growth of prostate cancer cells. In similar animal models, this compound decreases plasma PSA levels and suppresses tumor growth. Bicalutamide binds the androgen receptor in two sites, distorting coactivator binding and inhibiting transcription.

Optical rotation: [a]20 D= -83.~ – 85.0 (C=1, MeOH)

Product Info

Cas No.

113299-40-4
Purity

≥98%
Formula

C18H14F4N2O4S
Formula Wt.

430.37
Chemical Name

R-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4- fluorophenyl)sulfonyl)-2-hydroxy-2-methyl-, (+-)- Propanamide
IUPAC Name

(2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2- hydroxy-2-methylpropanamide
Melting Point

178-179°C
Solubility

water: 5mg/L
Appearance

White Crystalline powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

B3210 MSDS PDF
Info Sheet

B3210 Info Sheet PDF

References

Squillace RM, Miller D, Wardwell SD, et al. Synergistic activity of the mTOR inhibitor ridaforolimus and the antiandrogen bicalutamide in prostate cancer models. Int J Oncol. 2012 Aug;41(2):425-32. PMID: 22614157.

Yan J, Xie B, Capodice JL, et al. Zyflamend inhibits the expression and function of androgen receptor and acts synergistically with bicalutimide to inhibit prostate cancer cell growth. Prostate. 2012 Feb;72(3):244-52. PMID: 21656835.

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