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AG-1024

Product ID A2400
Cas No. 65678-07-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $62.80 In stock
5 mg $214.90 In stock
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  • Description
  • Product Info
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Description

AG-1024 is a tyrphostin that inhibits IGF-1R, exhibiting anticancer chemotherapeutic activity. In hepatocellular carcinoma cells and breast cancer cells, AG-1024 increases levels of cytochrome C, decreases activation of ERK, and inhibits invasion and proliferation.

Product Info

Cas No.

65678-07-1

Purity

≥98%

Formula

C14H13BrN2O

Formula Wt.

305.17

Chemical Name

2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile

IUPAC Name

2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile

Synonym

AG1024 (tyrphostin)

Solubility

DMSO 61 mg/mL (199.88 mM) Water Insoluble Ethanol Insoluble

Appearance

Light tan to light orange solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A2400 MSDS PDF

Info Sheet

A2400 Info Sheet PDF

References

Yao WF, Liu JW, Sheng GL, et al. Blockade of IGF-IR exerts anticancer effects in hepatocellular carcinoma. Mol Med Rep. 2011 Jul-Aug;4(4):719-22. PMID: 21567089.

Chakraborty AK, Welsh A, Digiovanna MP. Co-targeting the insulin-like growth factor I receptor enhances growth-inhibitory and pro-apoptotic effects of anti-estrogens in human breast cancer cell lines. Breast Cancer Res Treat. 2010 Apr;120(2):327-35. PMID: 19337828.

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