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Nutlin-3

Product ID N8277
Cas No. 548472-68-0
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $51.70 In stock
5 mg $177.60 In stock
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  • Description
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Description

Nutlin-3 is an imidazoline inhibitor of MDM2, preventing the interaction between MDM2 and p53. Nutlin-3 exhibits anticancer chemotherapeutic and anti-diabetic activities. Nutlin-3 increases production of ROS, activation of ERK1/2, p38 MAPK, and JNK, and increases expression of heme oxygenase 1 (HO-1) in colon cancer cells and osteosarcoma cells; similarly, it induces apoptosis in hepatocellular carcinoma cells. Nutlin-3 also inhibits the epithelial-to-mesenchymal transition (EMT), inhibiting phosphorylation of Smad2/3, suppressing cell motility, and enhancing the efficacy of other chemotherapeutics in animal models. In animal models of diabetes, this compound attenuates the effects of the disease, decreasing weight loss, increasing IL-12 production, and lowering rates of hyperglycemia.

Product Info

Cas No.

548472-68-0

Purity

≥95%

Formula

C30H30Cl2N4O4

Formula Wt.

581.49

Chemical Name

4-[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

IUPAC Name

4-[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

Synonym

Nutlin3

Solubility

DMSO 100 mg/mL (171.96 mM) Ethanol 30 mg/mL (51.59 mM) Water Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N8277 MSDS PDF

Info Sheet

N8277 Info Sheet PDF

References

Shi X, Liu J, Ren L, et al. Nutlin-3 downregulates p53 phosphorylation on serine(392) and induces apoptosis in hepatocellular carcinoma cells. BMB Rep. 2014 Apr;47(4):221-6. PMID: 24286312.

Choe YJ, Lee SY, Ko KW, et al. Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53. Int J Oncol. 2014 Mar;44(3):761-8. PMID: 24366007.

Wu Y, Fu Y, Zheng L, et al. Nutlin-3 inhibits epithelial-mesenchymal transition by interfering with canonical transforming growth factor-β1-Smad-Snail/Slug axis. Cancer Lett. 2014 Jan 1;342(1):82-91. PMID: 24001610.

Secchiero P, Toffoli B, Melloni E, et al. The MDM2 inhibitor Nutlin-3 attenuates streptozotocin-induced diabetes mellitus and increases serum level of IL-12p40. Acta Diabetol. 2013 Dec;50(6):899-906. PMID: 23615706.

Tisato V, Norcio A, Voltan R, et al. MDM2 non-genotoxic inhibitors as innovative therapeutic approaches for the treatment of pediatric malignancies. Curr Med Chem. 2013;20(17):2226-36. PMID: 23458617.

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