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Tianeptine Sodium Hydrate

Product ID T3203
Cas No. 30123-17-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $42.90 In stock
25 mg $179.00 In stock
50 mg $322.00 In stock
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  • Description
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Description

Tianeptine is an agonist at μORs and δORs as well as a potentiator at D2 and D3 DA receptors. Tianeptine exhibits neuromodulatory, antidepressant, anxiolytic, analgesic, anticonvulsant, and anti-inflammatory activities, although its mechanism of action is not well understood. In vitro, tianeptine inhibits LPS-induced inflammation and activation of microglia; is also decreases pro-inflammatory cytokine release, ROS release, and NF-κB activation. Clinically, this compound improves anxiety symptoms, neurocognitive function, and memory. Tianeptine also attenuates mechanical allodynia, an effect that may be mediated by 5-HT7 receptors.

Product Info

Cas No.

30123-17-2

Purity

≥98%

Formula

C21H24ClN2NaO4S

Formula Wt.

458.93

Chemical Name

sodium;7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoate

IUPAC Name

Sodium 7-[(3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoate

Synonym

Stablon, Coaxil

Solubility

DMSO: ≥20 mg/mL

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T3203 MSDS PDF

Info Sheet

T3203 Info Sheet PDF

References

Slusarczyk J, Trojan E, Glombik K, et al. Anti-inflammatory properties of tianeptine on lipopolysaccharide-induced changes in microglial cells involve Toll-like receptor-related pathways. J Neurochem. 2015 Dec 7. [Epub ahead of print]. PMID: 26640965.

Yoo I, Woo JM, Lee SH, et al. Influence of anxiety symptoms on improvement of neurocognitive functions in patients with major depressive disorder: A 12-week, multicenter, randomized trial of tianeptine versus escitalopram, the CAMPION study. J Affect Disord. 2015 Oct 1;185:24-30. PMID: 26142691.

Lin H, Heo BH, Kim WM, et al. Antiallodynic effect of tianeptine via modulation of the 5-HT7 receptor of GABAergic interneurons in the spinal cord of neuropathic rats. Neurosci Lett. 2015 Jun 26;598:91-5. PMID: 25982324.

Cooper CM, Whiting DA, Cowen PJ, et al. Tianeptine in an experimental medicine model of antidepressant action. J Psychopharmacol. 2015 May;29(5):582-90. PMID: 25759404.

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