Description
AM630 is a CB2 receptor antagonist. It is selective for CB2 over the CB1 receptor. AM630 activates TRPA1 in sensory neurons. This activation increases the hyperalgesic effect from capsaicin-induced pain models.
Product Info
| Cas No. | 164178-33-0 |
|---|---|
| Purity | ≥97% |
| Formula | C23H25IN2O3 |
| Formula Wt. | 504.37 |
| Chemical Name | 6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone |
| IUPAC Name | [6-iodo-2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]-(4-methoxyphenyl)methanone |
| Synonym | AM 630, Iodopravadoline |
| Solubility | 100mM in DMSO |
| Appearance | White to off-white powder |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Ross RA, Brockie HC, Stevenson LA, et al. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630. Br J Pharmacol. 1999 Feb;126(3):665-72. PMID: 10188977
Patil M, Patwardhan A, Salas MM, et al. Cannabinoid receptor antagonists AM251 and AM630 activate TRPA1 in sensory neurons. Neuropharmacology, 2011 Sep;61(4):778-88. PMID: 21645531.