LKT Labs

Biochemicals for Life Science Research

Lactacystin

Lactacystin

Product ID L0107
Cas No. 133343-34-7
Purity ≥98%
Product Unit SizeCostQuantityStock
100 µg $158.00 In stock
200 µg $278.00 In stock
500 µg $601.00 In stock
1 mg $1,127.00 Please Inquire
Bulk Quote

Quicklinks

Description

Lactacystin is a proteasome inhibitor initially produced by Streptomyces that exhibits hepatoprotective, anti-metastatic, and anticancer chemotherapeutic activities. Lactacystin increases the Bax/Bcl-2 ratio and inhibits proliferation of cells and growth of tumors in models of glioma. Additionally, lactacystin inhibits growth and migration of smooth muscle cells. In animal models of intestinal ischemia/reperfusion-induced liver injury, lactacystin inhibits activation of NF-κB, suppresses infiltration of neutrophils, and decreases levels of ICAM-1.

Product Info

Cas No.

133343-34-7
Purity

≥98%
Formula

C15H24N2O7S
Formula Wt.

376.43
IUPAC Name

(2R)-2-acetamido-3-[(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidine-2-carbonyl]sulfanylpropanoic acid
Solubility

Soluble DMSO or water.

Appearance

White Solid

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

L0107 MSDS PDF
Info Sheet

L0107 Info Sheet PDF

References

Wang H, Zhang S, Zhong J, et al. The proteasome inhibitor lactacystin exerts its therapeutic effects on glioma via apoptosis: an in vitro and in vivo study. J Int Med Res. 2013 Feb;41(1):72-81. PMID: 23569132.

Barringhaus KG, Matsumura ME. The proteasome inhibitor lactacystin attenuates growth and migration of vascular smooth muscle cells and limits the response to arterial injury. Exp Clin Cardiol. 2007 Fall;12(3):119-24. PMID: 18650992.

Yao JH, Li YH, Wang ZZ, et al. Proteasome inhibitor lactacystin ablates liver injury induced by intestinal ischaemia-reperfusion. Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1102-8. PMID: 17880361.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A5302

    Anastrozole

    Aromatase inhibitor.

    ≥99%
  • P9869

    Pyridoxine Hydrochloride

    Vitamin B6 derivative, antioxidant.

    ≥98%
  • F1745

    Felodipine

    Dihydropyridine; L-type Ca2+ channel blocker.

    ≥98%
  • T3098

    Thymosin β-4 Acetate

    Endogenous peptide; actin polymerization inhibi...

    ≥95%
  • M7200

    MS436

    BRD4 inhibitor.

    ≥99%
  • G4479

    Glucagon (19-29), human

    Endogenous peptide hormone, glugagon fragment; ...

    ≥95%
  • C000170

    C170

    STING inhibitor

    ≥98%
  • N8561

    NVP-AEW541

    IGF-1R inhibitor.

    ≥98%
  • R1876

    all-trans-Retinol

    Diterpene component of vitamin A, differentiati...

    ≥95%
  • F465817

    Flunisolide

    Corticosteroid

    ≥90%
  • R3011

    Recombinant TpN 15 protein

    Recombinant protein containing Treponema pallid...

    ≥95%
  • A5235

    Amitriptyline Hydrochloride

    FIASMA, σ1, RyR2, TrkA/B agonist; SERT, NET in...

    ≥98%
  • E0003

    E64-d

    Cathepsin inhibitor.

    ≥97%
  • P2304

    Phalloidin

    Phallotoxin found in Amanita phalloides; microt...

    ≥90%
  • J5237

    JNJ-26854165

    MDM2 inhibitor.

    ≥98%
  • R2714

    Recombinant HCV-NS5 Antigens

    Recombinant HCV antigen fragment.

    ≥95%
  • C2970

    Chrysophanol

    Anthraquinone found in Rheum.

    ≥98%
  • R3373

    Risedronate Sodium Hydrate

    Bisphosphonate; inhibits transfer of farnesyl p...

    ≥98%
  • M2076

    Metformin Hydrochloride

    AMPK activator.

    ≥98%
  • C2818

    Chelerythrine Chloride

    benzophenanthridine alkaloid found in Chelidoni...

    ≥98%