LKT Labs

Biochemicals for Life Science Research

Lactacystin

Lactacystin

Product ID L0107
Cas No. 133343-34-7
Purity ≥98%
Product Unit SizeCostQuantityStock
100 µg $157.80 In stock
200 µg $277.90 In stock
500 µg $601.00 In stock
1 mg $1,126.90 Please Inquire
Bulk Quote

Quicklinks

Description

Lactacystin is a proteasome inhibitor initially produced by Streptomyces that exhibits hepatoprotective, anti-metastatic, and anticancer chemotherapeutic activities. Lactacystin increases the Bax/Bcl-2 ratio and inhibits proliferation of cells and growth of tumors in models of glioma. Additionally, lactacystin inhibits growth and migration of smooth muscle cells. In animal models of intestinal ischemia/reperfusion-induced liver injury, lactacystin inhibits activation of NF-κB, suppresses infiltration of neutrophils, and decreases levels of ICAM-1.

Product Info

Cas No.

133343-34-7
Purity

≥98%
Formula

C15H24N2O7S
Formula Wt.

376.43
IUPAC Name

(2R)-2-acetamido-3-[(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidine-2-carbonyl]sulfanylpropanoic acid
Solubility

Soluble DMSO or water.

Appearance

White Solid

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

L0107 MSDS PDF
Info Sheet

L0107 Info Sheet PDF

References

Wang H, Zhang S, Zhong J, et al. The proteasome inhibitor lactacystin exerts its therapeutic effects on glioma via apoptosis: an in vitro and in vivo study. J Int Med Res. 2013 Feb;41(1):72-81. PMID: 23569132.

Barringhaus KG, Matsumura ME. The proteasome inhibitor lactacystin attenuates growth and migration of vascular smooth muscle cells and limits the response to arterial injury. Exp Clin Cardiol. 2007 Fall;12(3):119-24. PMID: 18650992.

Yao JH, Li YH, Wang ZZ, et al. Proteasome inhibitor lactacystin ablates liver injury induced by intestinal ischaemia-reperfusion. Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1102-8. PMID: 17880361.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M0248

    Manidipine Dihydrochloride

    Dihydropyridine; L-type and T-type Ca2+ channel...

    ≥99%
  • G7862

    GTPL-5846

    GPR84 agonist.

    ≥98%
  • E6783

    R-Equol

    Isoflavone, phytoestrogen found in soy

    ≥98%
  • N8760

    NVP-TAE684

    ALK, c-Fes, LRRK2 inhibitor.

    ≥98%
  • T2800

    Thalidomide

    Immunomodulator; teratogen.

    ≥98%
  • S3343

    Silybin

    Flavonoid originally found in Silybum (milk thi...

    ≥97%
  • L1340

    LDK378

    ALK and IGF-1R inhibitor.

    ≥99%
  • E537334

    Enniatin B

    Mycotoxin contaminant found in cereal grains.

    ≥98%
  • S8012

    [Sar9]-Substance P

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • M1774

    2-Mercaptoethanesulfonate Sodium

    Organosulfur, antioxidant.

    ≥98%
  • T1674

    Terbutaline Sulfate

    β2-adrenergic agonist, potential ENaC activato...

    ≥98%
  • B3275

    Bis(3,5-dibromosalicyl) Succinate

    Aspirin analog; hemoglobin chain cross-linker.<...

    ≥95%
  • D1774

    Desloratadine

    Loratadine metabolite; FIASMA, histamine H1 ant...

    ≥97%
  • S7872

    Stresscopin-Related Peptide, human

    Peptide, urocortin II analog; CRFR2 agonist.

    ≥95%
  • P7057

    Protodioscin

    Saponin found in Dioscorea; Na+/K+ ATPase and C...

    ≥98%
  • C0022

    Cafestol Palmitate

    Diterpene found in brewed, unfiltered coffee; F...

    ≥97%
  • C179602

    CEP-28122

    ALK inhibitor.

    ≥98%
  • F4584

    Fluphenazine Hydrochloride

    Piperazine; FIASMA, D2 antagonist, hERG K+ chan...

    ≥97%
  • T3100

    Thyrotropin-releasing Hormone

    Endogenous tripeptide, involved in HPA signalin...

    ≥95%
  • P0013

    P7C3

    Aminopropyl carbazole, neuroprotective.

    ≥98%