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Thalidomide

Product ID T2800
Cas No. 50-35-1
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $50.80 In stock
100 mg $84.90 In stock
250 mg $170.00 In stock
500 mg $250.00 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Thalidomide has previously been clinically used as a sedative but was found to induce birth defects in pregnant females. Recently, thalidomide exhibits anticancer chemotherapeutic potential in the treatment of multiple myeloma. Additionally, thalidomide displays anti-inflammatory and immunomodulatory activities, improving TNBS-induced colitis in animal models by increasing expression of IL-10 and decreasing expression of TNF-α and IL-1β.

Product Info

Cas No.

50-35-1

Purity

≥98%

Formula

C13H10N2O4

Formula Wt.

258.23

Chemical Name

(±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

IUPAC Name

2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

Synonym

1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline, Actimid, Calmore, Distaval, Sedimide,Telagan

Melting Point

269-271°C

Solubility

Insoluble in water and ethanol. Soluble in DMSO (56 mg/mL).

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T2800 MSDS PDF

Info Sheet

T2800 Info Sheet PDF

References

Lien IC, Horng LY, Hsu PL, et al. Internal ribosome entry site of bFGF is the target of thalidomide for IMiDs development in multiple myeloma. Genes Cancer. 2014 Mar;5(3-4):127-41. PMID: 25053990.

Xu J, Zheng C, Huang Y, et al. Efficacy of thalidomide on trinitrobenzene sulfonate-induced colitis in young rats and its mechanism. Chin Med J (Engl). 2014;127(12):2368-75. PMID: 24931258.

Zhou S, Wang F, Hsieh TC, et al. Thalidomide-a notorious sedative to a wonder anticancer drug. Curr Med Chem. 2013;20(33):4102-8. PMID: 23931282.

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