• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Cilnidipine

Cilnidipine

Product ID C3446
Cas No. 132203-70-4
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $110.40 In stock
100 mg $211.40 In stock
250 mg $352.30 In stock
1 g $1,014.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Cilnidipine is a dihydropyridine that exhibits antihypertensive, vasodilatory, antinociceptive, and nephroprotective activities. Cilnidipine acts as an antagonist at L-type and N-type voltage-gated Ca2+ channels. In subjects with hypertension, cilnidipine decreases blood pressure and urinary albumin excretion. Cilnidipine also increases expression of eNOS ex vivo in thoracic arteries. In animal models of non insulin-dependent diabetes, cilnidipine improves insulin sensitivity, indicating potential anti-diabetic activity as well. This compound inhibits nociception in animal models undergoing the formalin test. Additionally, in vitro, cilnidipine decreases production of AP-1, TGF-β, and fibronectin, inhibiting proliferation of mesangial cells; in similar animal models, cilnidipine inhibits progression of glomerulonephritis.

Product Info

Cas No.

132203-70-4

Purity

≥98%

Formula

C27H28N2O7

Formula Wt.

492.52

IUPAC Name

3-O-(2-methoxyethyl) 5-O-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Melting Point

97-99°C

Solubility

DMSO (>25 mg/mL), ethanol (20 mg/mL). Insoluble in water.

Appearance

Light yellow crystal powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C3446 MSDS PDF

Info Sheet

C3446 Info Sheet PDF

References

Soeki T, Kitani M, Kusunose K, et al. Renoprotective and antioxidant effects of cilnidipine in hypertensive patients. Hypertens Res. 2012 Nov;35(11):1058-62. PMID: 22763473.

Fan L, Yang Q, Xiao XQ, et al. Dual actions of cilnidipine in human internal thoracic artery: inhibition of calcium channels and enhancement of endothelial nitric oxide synthase. J Thorac Cardiovasc Surg. 2011 Apr;141(4):1063-9. PMID: 20599230.

Koganei H, Shoji M, Iwata S. Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker. Biol Pharm Bull. 2009 Oct;32(10):1695-700. PMID: 19801830.

Sugiura T, Imai E, Moriyama T, et al. Calcium channel blockers inhibit proliferation and matrix production in rat mesangial cells: possible mechanism of suppression of AP-1 and CREB activities. Nephron. 2000 May;85(1):71-80. PMID: 10773759.

Harada N, Ohnaka M, Sakamoto S, et al. Cilnidipine improves insulin sensitivity in the Otsuka Long-Evans Tokushima fatty rat, a model of spontaneous NIDDM. Cardiovasc Drugs Ther. 1999 Nov;13(6):519-23. PMID: 10686661.

Fan YY, Kohno M, Nakano D, et al. Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats: possible involvement of N-type calcium channel in podocyte. J Hypertens. 2010 May;28(5):1034-1043. PMID: 20411599.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C0269

    β-Carotene

    Red-orange terpene pigment found in various pla...

    ≥98%
  • R7680

    Recombinant M. Tuberculosis Antigen TB 38+6+10

    Tuberculosis antigen

  • M174446

    Meleagrin

    FabI inhibitor

    ≥99%
  • N1894

    Nexturastat A

    HDAC6 inhibitor.

    ≥98%
  • I6932

    Irinotecan

    Camptothecin analog; topoisomerase I inhibitor,...

    ≥98%
  • F4518

    Fleroxacin

    Fluoroquinolone; bacterial DNA gyrase and helic...

    ≥98%
  • B030960

    BAY-1082439

    PI3K inhibitor.

    ≥98%
  • S8098

    SU-1498

    Tyrphostin; VEGFR inhibitor.

    ≥99%
  • S822687

    Surfactin

    Amphiphilic properties

    ≥90% mixed isomers
  • C0243

    Calcitonin Gene Related Peptide (8-37), human

    Calcitonin-family peptide frgament, involved in...

    ≥95%
  • A8644

    AVL-292

    BTK inhibitor.

    ≥98%
  • G4434

    Gliotoxin

    Toxin produced by Aspergillus.

    ≥98%
  • A0910

    N-Acetyl-S-(N′-phenylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant.

    ≥98%
  • B3278

    Biotin

    Water-soluble coenzyme, vitamin (B7) found in v...

    ≥98%
  • N5550

    Nomilin

    Triterpene found in species of Citrus; HIV-1 pr...

    ≥98%
  • D3357

    Diosmin

    Flavone found in Teucrium.

    ≥95%
  • R0161

    Rapamycin

    Macrolide originally produced by Streptomyces; ...

    ≥99%
  • L8276

    Luteinizing Hormone Releasing Hormone

    Endogenous peptide hormone; GnRH agonist.

    ≥98%
  • L930280

    LXH254

    pan-RAF inhibitor

    ≥99%
  • P6801

    Pravastatin Sodium

    Statin; HMG-CoA reductase inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only