Name: LXH254
SKU: L930280
Availability: InStock

Description

LXH254 is a type II RAF inhibitor.

Product Info

Cas No.	1800398-38-2
Purity	≥99%
Formula	C₂₅H₂₅F₃N₄O₄
Formula Wt.	502.49
IUPAC Name	N-[3-[2-(2-hydroxyethoxy)-6-morpholin-4-ylpyridin-4-yl]-4-methylphenyl]-2-(trifluoromethyl)pyridine-4-carboxamide
Synonym	Naporafenib
Appearance	White powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

Info Sheet	L930280 Info Sheet PDF

References

Monaco K, Delach S, Yuan J, et al. LXH254, a potent and selective ARAF-sparing inhibitor of BRAF and CRAF for the treatment of MAPK-driven tumors. Clin Cancer Res. 2021 Apr 1;27(7):2061-2073. PMID: 33355204

Park S, Kim T, Cho S, et al. Combined blockade of polo-like kinase and pan-RAF is effective against NRAS-mutant non-small cell lung cancer cells. Cancer Lett. 2020 Dec 28;495:135-144. PMID: 32979462

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LXH254

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