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Sofosbuvir

Product ID S5722
Cas No. 1190307-88-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $88.60 In stock
5 mg $136.40 In stock
10 mg $245.40 In stock
25 mg $443.00 In stock
50 mg $681.50 In stock
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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
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  • Downloads
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Description

Sofosbuvir is an antiviral compound that inhibits viral RNA polymerase. Sofosbuvir is clinically used to treat hepatitis C infection. This compound is a prodrug that is metabolized to a more active intermediate.

Product Info

Cas No.

1190307-88-0

Purity

≥98%

Formula

C22H29FN3O9P

Formula Wt.

529.45

IUPAC Name

propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate

Solubility

DMSO 100 mg/mL warmed (188.87 mM) Ethanol 100 mg/mL (188.87 mM) Water 11 mg/mL warmed (20.77 mM)

Appearance

Yellow to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

S5722 MSDS PDF

Info Sheet

S5722 Info Sheet PDF

References

Murakami C, Melda Urekli H, Atta MG. Antiviral medications for the treatment of hepatitis B and C infection and their effects on kidney function. Minerva Gastroenterol Dietol. 2014 Sep;60(3):177-89. PMID: 25027705.

Fung A, Jin Z, Dyatkina N, et al. Efficiency of incorporation and chain termination determines the inhibition potency of 2'-modified nucleotide analogs against hepatitis C virus polymerase. Antimicrob Agents Chemother. 2014 Jul;58(7):3636-45. PMID: 24733478.

Murakami E, Tolstykh T, Bao H, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285(45):34337-47. PMID: 20801890.

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