Description
Phorbol-12-myristate-13-acetate (PMA) activates PKC and induces DNA damage. PMA exhibits pro-inflammatory, carcinogenic, and cytotoxic activities. This compound is often used in research models as a tumor promoter.
Phorbol-12-myristate-13-acetate
Product ID P2857
Cas No. 16561-29-8
Purity ≥98%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 16561-29-8 |
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| Purity | ≥98% |
| Formula | C36H56O8 |
| Formula Wt. | 616.84 |
| Chemical Name | 12-Tetradecanoyl phorbol-13-acetate |
| IUPAC Name | [(1S,2S,6R,10S,11R,13S,14R,15R)-13-acetyloxy-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxo-14-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] tetradecanoate |
| Synonym | TPA, PMA, Tetradecanoylphorbol acetate, 4beta-Phorbol 12-myristate 13-acetate, Phorbol ester |
| Melting Point | 50-70°C |
| Solubility | Soluble in DMSO, methanol, ethanol, ethyl acetate, or chloroform. Insoluble in water or aqueous buffer. |
| Appearance | Colorless Liquid |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Poachanukoon O, Koontongkaew S, Monthanapisut P, et al. Macrolides attenuate phorbol ester-induced tumor necrosis factor-α and mucin production from human airway epithelial cells. Pharmacology. 2014;93(1-2):92-9. PMID: 24556631.
Oskoueian E, Abdullah N, Ahmad S. Phorbol esters isolated from Jatropha meal induced apoptosis-mediated inhibition in proliferation of chang and Vero cell lines. Int J Mol Sci. 2012 Oct 24;13(11):13816-29. PMID: 23203036.
Colombo D, Tringali C, Franchini L, et al. Glycoglycerolipid analogues inhibit PKC translocation to the plasma membrane and downstream signaling pathways in PMA-treated fibroblasts and human glioblastoma cells, U87MG. Eur J Med Chem. 2011 May;46(5):1827-34. PMID: 21388717.
Birnboim HC. Factors which affect DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate. Can J Physiol Pharmacol. 1982 Nov;60(11):1359-66. PMID: 6295575.