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Bromosporine

Product ID B6959
Cas No. 1619994-69-2
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $142.60 In stock
5 mg $493.00 Please Inquire
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Bromosporine is an inhibitor of BET bromodomains (BRDs) BRD2, BRD4, BRD9, and CECR2; it may exhibit anticancer potential. It has been found to have a synergistic effect with 5-fluorouracil against colorectal cancer cells. Bromosporine is also effective with in vitro studies in reactivating latent HIV-1 reservoirs in order to eradicate the disease through a “shock and kill” strategy.

Product Info

Cas No.

1619994-69-2

Purity

≥99%

Formula

C17H20N6O4S

Formula Wt.

404.44

Chemical Name

ethyl N-[6-[3-(methanesulfonamido)-4-methylphenyl]-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate

IUPAC Name

ethyl N-[6-[3-(methanesulfonamido)-4-methylphenyl]-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate

Synonym

N-[6-(3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate; GTPL8234

Solubility

DMSO 81 mg/mL (200.27 mM) Water Insoluble Ethanol Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B6959 MSDS PDF

Info Sheet

B6959 Info Sheet PDF

References

Cheng X, Huang Z, Long D, et al. BET inhibitor bromosporine enhances 5-FU effect in colorectal cancer cells. Biochem Biophys Res Commun. 2020 Jan 22;521(4):840-845. PMID: 31708100.

Pan H, Lu P, Shen Y, et al. The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells. Oncotarget. 2017 Oct 6;8(55):94104-94116. PMID: 29212213.

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