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Calcium Folinate Pentahydrate

Product ID C0147
Cas No. 6035-45-6
Purity ≥95%
Product Unit SizeCostQuantityStock
100 mg $88.10 In stock
500 mg $371.40 In stock
1 g $623.60 In stock
Bulk Quote

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  • Product Info
  • Shipping and Storage
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  • Description
  • Product Info
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Description

Calcium folinate is commonly co-administered with methotrexate or other similar chemotherapeutics to provide a folate source for some dividing cells, such as bone marrow cells. Calcium folinate may inhibit thymidylate synthase.

Product Info

Cas No.

6035-45-6

Purity

≥95%

Formula

C20H21CaN7O7 5H2O

Formula Wt.

601.59

Chemical Name

N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4- oxo-6-pteridinyl)methyl]-amino]benzoyl]-L-glutamic acid calcium salt pentahydrate

IUPAC Name

calcium;2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate;pentahydrate

Synonym

Leucovorin, 5-Formyl-5,6,7,8-tetrahydrofolic acid, calcium salt

Melting Point

240-250°C

Solubility

Soluble in water. Insoluble in ethanol.

Appearance

Pale yellow powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C0147 MSDS PDF

Info Sheet

C0147 Info Sheet PDF

References

Chen C, Tian L, Zhang M, et al. Protective effect of amifostine on high-dose methotrexate-induced small intestinal mucositis in mice. Dig Dis Sci. 2013 Nov;58(11):3134-43. PMID: 23979434.

Payet B, Fabre G, Tubiana N, et al. Plasma kinetic study of folinic acid and 5-methyltetrahydrofolate in healthy volunteers and cancer patients by high-performance liquid chromatography. Cancer Chemother Pharmacol. 1987;19(4):319-25. PMID: 3496173.

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