• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Rosiglitazone Maleate

Rosiglitazone Maleate

Product ID R5772
Cas No. 155141-29-0
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $71.70 In stock
100 mg $126.30 In stock
500 mg $233.60 In stock
1 g $340.30 In stock
5 g $875.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Rosiglitazone is a thiazolidinedione insulin sensitizer that activates PPARγ, decreasing blood glucose and insulin levels. Rosiglitazone exhibits anti-diabetic, anti-inflammatory, antioxidative, anticancer, anti-angiogenic, antihypertensive, and anti-fibrotic activities. In vivo, rosiglitazone decreases LPS-stimulated production of TNF-α, IL-1β, and IL-6 as well as activity of myeloperoxidase; it also inhibits activation of NF-κB, preventing mastitis. In multiple myeloma cells, rosiglitazone suppresses expression of HIF-1α and IGF-1, decreases activation of Aky, and Erk, and inhibits cell viability and proliferation. This compound also inhibits endothelin-1-induced vasoconstriction in a NO-dependent manner in animal models of pulmonary arterial hypertension. Additionally, rosiglitazone prevents activation of AP-1, production of collagen, and differentiation in fibroblasts.

Product Info

Cas No.

155141-29-0

Purity

≥98%

Formula

C18H19N3O3S • C4H4O4

Formula Wt.

473.51

Chemical Name

5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione

IUPAC Name

(Z)-but-2-enedioic acid;5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1, 3-thiazolidine-2,4-dione

Synonym

BRL-49653c, Avandia

Melting Point

122-123°C

Solubility

Readily soluble in ethanol and in buffered aqueous solutions with a pH of 2.3.

Appearance

White Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

R5772 MSDS PDF

Info Sheet

R5772 Info Sheet PDF

References

Rui M, Huang Z, Liu Y, et al. Rosiglitazone suppresses angiogenesis in multiple myeloma via downregulation of hypoxia inducible factor 1α and insulin like growth factor 1 mRNA expression. Mol Med Rep. 2014 Jul 22. [Epub ahead of print]. PMID: 25050627.

Mingfeng D, Xiaodong M, Yue L, et al. Effects of PPAR-γ Agonist Treatment on LPS-Induced Mastitis in Rats. Inflammation. 2014 May 18. [Epub ahead of print]. PMID: 24839089.

Liu Y, Tian XY, Huang Y, et al. Rosiglitazone Attenuated Endothelin-1-Induced Vasoconstriction of Pulmonary Arteries in the Rat Model of Pulmonary Arterial Hypertension via Differential Regulation of ET-1 Receptors. PPAR Res. 2014;2014:374075. PMID: 24701204.

He H, Tao H, Xiong H, et al. Rosiglitazone causes cardiotoxicity via peroxisome proliferator-activated receptor γ-independent mitochondrial oxidative stress in mouse hearts. Toxicol Sci. 2014 Apr;138(2):468-81. PMID: 24449420.

Hou X, Zhang Y, Shen YH, et al. PPAR-γ activation by rosiglitazone suppresses angiotensin II-mediated proliferation and phenotypictransition in cardiac fibroblasts via inhibition of activation of activator protein 1. Eur J Pharmacol. 2013 Sep 5;715(1-3):196-203. PMID: 23791613.

Sharma AN, Elased KM, Lucot JB. Rosiglitazone treatment reversed depression- but not psychosis-like behavior of db/db diabetic mice. J Psychopharmacol. 2012 May;26(5):724-732. PMID: 22331176.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C4534

    Clindamycin Palmitate Hydrochloride

    Lincosamide; ribosomal translocation and protei...

    ≥98%
  • P6954

    Pioglitazone Hydrochloride

    Thiazolidinedione; PPARα/γ agonist, mitoNEET ...

    ≥98%
  • L589921

    Loxapine Succinate

    D2 and D4 dopamine receptor inhibitor.

    ≥99%
  • C3352

    Cinacalcet Hydrochloride

    Ca2+-sensing receptor agonist.

    ≥99%
  • T6834

    Triacsin C

    Acyl-CoA synthetase inhibitor.

    ≥95%
  • C5592

    CNX-774

    BTK inhibitor.

    ≥98%
  • P7000

    PR-619

    Deubiquitinating enzyme inhibitor.

    ≥98%
  • R5745

    Rolipram

    Anxiolytic-like agent that stimulates angiogene...

    ≥98%
  • F334451

    Filipin Complex

    A probe for cholesterol in biological membranes...

    ≥97%
  • S0133

    Saikosaponin C

    Triterpene saponin found in Bupleurum.

    ≥98%
  • T174441

    Telacebec

    Anti-tuberculosis

    ≥98%
  • M1769

    Meropenem Trihydrate

    β-lactam carbapenem; penicillin binding protei...

    ≥98%
  • B1979

    Betulinic Acid

    Pentacyclic triterpene.

    ≥99%
  • A985134

    AZD-9291

    EGFR inhibitor.

    ≥99%
  • I7757

    Itopride Hydrochloride

    AChE inhibitor, D2 antagonist.

    ≥98%
  • A5234

    Amisulpride

    5-HT7 and D2/3 antagonist.

    ≥98%
  • J889290

    JWH 133

    Cannabinoid receptor 2 selective agonist.

    ≥95%
  • E5178

    Emtricitabine

    Nucleoside (cytidine) analog; RT and telomerase...

    ≥98%
  • A2050

    Aflatoxin G2

    Mycotoxin produced by species of Aspergillus; D...

    ≥98%
  • N5986

    Novobiocin Sodium

    Aminocoumarin; bacterial DNA gyrase inhibitor.<...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only