Description
GW405833 is a selective cannabinoid receptor 2 (CB2) agonist. It shows activity in pancreatic cancer mouse models and reduces the number of Ca2+ ocilllations in pancreatic acinar cells, which is a cause of pancreatitis.
Product Info
| Cas No. | 180002-83-9 |
|---|---|
| Purity | ≥98% |
| Formula | C23H24Cl2N2O3 |
| Formula Wt. | 447.356 |
| Chemical Name | (2,3-dichlorophenyl)-[5-methoxy-2-methyl-3-(2-morpholin-4-ylethyl)indol-1-yl]methanone |
| IUPAC Name | (2,3-dichlorophenyl)-[5-methoxy-2-methyl-3-(2-morpholin-4-ylethyl)indol-1-yl]methanone |
| Synonym | L-768,242, GW405833 |
| Solubility | 50mM in DMSO, 50mM in ethanol |
| Appearance | Tan powder |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Huang Z, Wang H, Wang J et al. Cannabinoid receptor subtype 2 (CB2R) agonist, GW405833 reduces agonist-induced Ca(2+) oscillations in mouse pancreatic acinar cells. Sci Rep. 2016 Jul 19:6:29757. PMID: 27432473.
Mancini I, Brusa R, Quadrato G et al. Constitutive activity of cannabinoid-2 (CB2) receptors plays an essential role in the protean agonism of (+)AM1241 and L768242. Br J Pharmacol. 2009 Sep;158(1):382-91. PMID: 19552692.