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Benfotiamine

Benfotiamine

Product ID B1753
Cas No. 22457-89-2
Purity ≥98%
Product Unit SizeCostQuantityStock
250 mg $78.40 In stock
1 g $156.50 In stock
5 g $326.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Benfotiamine is a synthetic, lipid-soluble derivative of the B vitamin thiamine. Benfotiamine exhibits antinociceptive, neuroprotective, and anti-inflammatory activities. In animal models, benfotiamine inhibits pain signaling in a prostatic acid phosphatase-dependent manner. In vitro, benfotiamine decreases production of amyloid-β (Aβ) and downregulates activity of glycogen synthase kinase 3 (GSK3). In macrophages, this compound inhibits LPS-induced activation of phospholipase A2 (PLA2), release of leukotrienes, prostaglandins, and thromboxane B2 (TxB2), and also suppresses oxidative stress. Benfotiamine also decreases oxidative stress induced by streptozocin in animal models.

Product Info

Cas No.

22457-89-2

Purity

≥98%

Formula

C19H23N4O6PS

Formula Wt.

466.453

Chemical Name

S-Benzoylthiamine O-monophosphate

IUPAC Name

S-[(Z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5- phosphonooxypent-2-en-3-yl] benzenecarbothioate

Melting Point

~200°C

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

B1753 MSDS PDF

Info Sheet

B1753 Info Sheet PDF

References

Wang K, Han C, Yang J, et al. Benfotiamine protects MPTP-induced Parkinson’s disease mouse model via activating Nrf2 signaling pathway. PLoS One. 2024 Jul 23;19(7):e0307012. PMID: 39042624.

Hurt JK, Coleman JL, Fitzpatrick BJ, et al. Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine. PLoS One. 2012;7(10):e48562. PMID: 23119057.

Sun XJ, Zhao L, Zhao N, et al. Benfotiamine prevents increased β-amyloid production in HEK cells induced by high glucose. Neurosci Bull. 2012 Oct;28(5):561-6. PMID: 22961478.

Shoeb M, Ramana KV. Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages. Free Radic Biol Med. 2012 Jan 1;52(1):182-90. PMID: 22067901.

Wu S, Ren J. Benfotiamine alleviates diabetes-induced cerebral oxidative damage independent of advanced glycation end-product, tissue factor and TNF-alpha. Neurosci Lett. 2006 Feb 13;394(2):158-62. PMID: 16260089.

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