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RGDS

Product ID R2513
Cas No. 91037-65-9
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $111.40 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

RGDS is a tetrapeptide that delivers attached compounds to targets such as thrombus or tumor cells; it enhances efficacy of anticancer and anti-aggregation or anti-adhesion compounds. RDGS binds integrins on the surfaces of cells. RGDS also exhibits anti-inflammatory benefit, improving ventilation-induced lung injury by preventing activation of NF-κB and suppressing production of TNF-α and IL-6 in vivo.

Product Info

Cas No.

91037-65-9

Purity

≥95%

Formula

C15H27N7O8

Formula Wt.

433.4

Chemical Name

Arginyl-glycyl-aspartyl-serine

IUPAC Name

3-[[2-[[2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino] -4-[(1-carboxy-2-hydroxyethyl)amino]-4-oxobutanoic acid

Synonym

Fibronectin tetrapeptide

Solubility

Soluble in water (1 mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

R2513 MSDS PDF

Info Sheet

R2513 Info Sheet PDF

References

Inoue T, Hashimoto R, Matsumoto A, et al. In vivo Analysis of Arg-Gly-Asp Sequence/Integrin α5β1-Mediated Signal Involvement in Embryonic Enchondral Ossification by exo utero Development System. J Bone Miner Res. 2013 Dec 27. [Epub ahead of print]. PMID: 24375788.

Wang B, Wan JY, Zhang L, et al. Synthetic RGDS peptide attenuates mechanical ventilation-induced lung injury in rats. Exp Lung Res. 2012 May;38(4):204-10. PMID: 22452721.

Zhao M, Wang C, Jiang X, et al. Synthesis of RGD containing peptides and their bioactivities. Prep Biochem Biotechnol. 2002 Nov;32(4):363-80. PMID: 12455829.

Preferred conformations of RGDX tetrapeptides to inhibit the binding of fibrinogen to platelets.
Park HS, Kim C, Kang YK. Biopolymers. 2002 Apr 15;63(5):298-313. PMID: 11877740.

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