• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Isatin

Isatin

Product ID I7302
Cas No. 91-56-5
Purity ≥97%
Product Unit SizeCostQuantityStock
100 g $61.10 In stock
500 g $204.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Isatin is an indole derivative found in Isatis, Calanthe, and Couroupita that exhibits anti-inflammatory, antioxidative, neuromodulatory, and anticancer chemotherapeutic activities. Isatin prevents TNBS-induced increases in TNF-α, COX-2, and PGE2 levels as well as decreases in SOD and GSH levels, protecting against colitis-induced injuries in animal models. Isatin also inhibits monoamine oxidase B (MAO-B) and guanylate cyclase (natriuretic peptide receptors). Schiff base derivatives of isatin inhibit the growth of various cancer cells and tumors, likely due to decreasing cyclin B1 and Cdc2 expression and inducing G2/M phase cell cycle arrest. Derivatives of isatin also inhibit tubulin polymerization, Akt activation, and caspases 3, 7, and 9. Isatin may also exhibit antiepileptic/anticonvulsant activity.

Product Info

Cas No.

91-56-5

Purity

≥97%

Formula

C8H5NO2

Formula Wt.

147.13

Chemical Name

Indole-2,3-dione

IUPAC Name

1H-indole-2,3-dione

Synonym

2,3-Indolinedione, 2,3-Diketoindoline

Melting Point

203.5°C (partial subliminati°n)

Solubility

Soluble in boiling alcohol, ether, boiling water and alkali hydroxide.

Appearance

Red Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

I7302 MSDS PDF

Info Sheet

I7302 Info Sheet PDF

References

Liang C, Xia J, Lei D, et al. Synthesis, in vitro and in vivo antitumor activity of symmetrical bis-Schiff base derivatives of isatin. Eur J Med Chem. 2014 Mar 3;74:742-50. PMID: 24176732.

Socca EA, Luiz-Ferreira A, de Faria FM, et al. Inhibition of tumor necrosis factor-alpha and cyclooxigenase-2 by Isatin: a molecular mechanism of protection against TNBS-induced colitis in rats. Chem Biol Interact. 2014 Feb 25;209:48-55. PMID: 24316276.

Krishnegowda G, Prakasha Gowda AS, Tagaram HR, et al. Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway. Bioorg Med Chem. 2011 Oct 15;19(20):6006-14. PMID: 21920762.

Chu W, Rothfuss J, d'Avignon A, et al. Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors. J Med Chem. 2007 Jul 26;50(15):3751-5. PMID: 17585855.

Malawska B. New anticonvulsant agents. Curr Top Med Chem. 2005;5(1):69-85. PMID: 15638779.

Edmondson DE, Mattevi A, Binda C, et al. Structure and mechanism of monoamine oxidase. Curr Med Chem. 2004 Aug;11(15):1983-93. PMID: 15279562.

Medvedev AE, Sandler M, Glover V. Interaction of isatin with type-A natriuretic peptide receptor: possible mechanism. Life Sci. 1998;62(26):2391-8. PMID: 9651105.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R1876

    all-trans-Retinol

    Diterpene component of vitamin A, differentiati...

    ≥95%
  • R1627

    Regorafenib Anhydrous

    Multikinase inhibitor.

    ≥99%
  • L1881

    Leuprolide Acetate

    GnRH analog; GnRH1 agonist.

    ≥95%
  • E7377

    Estriol

    Endogenous steroid hormone, estradiol metabolit...

    ≥97%
  • F4584

    Fluphenazine Hydrochloride

    Piperazine; FIASMA, D2 antagonist, hERG K+ chan...

    ≥97%
  • R6052

    Recombinant Mycoplasma Pneumonia Antigen

    Pneumonia antigen

  • R2712

    Recombinant HCV-NS3 Antigens

    Recombinant HCV antigen fragment.

    ≥95%
  • C9710

    Cyclopamine

    Steroidal jerveratrum alkaloid found in Veratru...

    ≥98%
  • C0254

    Candesartan Celexetil Ester

    AT1 inhibitor.

    ≥98%
  • T4400

    TL-32711

    Smac mimetic; IAP inhibitor.

    ≥98%
  • T7134

    trans-3,4′,5-Trimethoxy Stilbene

    Resveratrol prodrug; potential SIRT1 activator....

    ≥99%
  • M568264

    Mogroside IIe

    Triterpenoid

    ≥98%
  • E5214

    α-Endorphin

    Endogenous opioid peptide; μOR agonist.

    ≥95%
  • H174466

    Helvolic acid

    A fungal metabolite that inhibits protein synth...

    ≥98%
  • G0247

    2″O-Galloylhyperin

    Flavonoid glycoside found in Pyrola.

    ≥98%
  • V0273

    Vasoactive Intestinal Peptide

    Endogenous peptide hormone, involved in enteric...

    ≥95%
  • B8676

    BVT-2733

    11β-HSD1 inhibitor.

    ≥98%
  • N5652

    Nonactin

    Naturally-ocurring neurtral cyclic ionophore, m...

    ≥95%, TLC
  • C0151

    α-Calcitonin Gene Related Peptide, human

    Endogenous calcitonin-family peptide, involved ...

    ≥95%
  • D3261

    Dipropyl Disulfide

    Organosulfide found in Allium; cholesterol synt...

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only