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Helvolic acid

Product ID H174466
Cas No. 29400-42-8
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $91.30 In stock
5 mg $408.90 In stock
10 mg $661.00 In stock
Bulk Quote

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  • Product Info
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  • Description
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Description

Helvolic acid is a well-known fungal metabolite that inhibits protein synthesis through elongation factor G on the bacterial ribosome. It has shown in vitro antitrypanosomal activity against Trypanosoma brucei brucei GUTat3.1 with IC50 value of 5.08 µg/mL. Helvolic acid has also been found to be weakly cytotoxic against normal human diploid fibroblasts with IC50 value of >100 µg/mL. Furthermore, Helvolic acid has shown to exhibit strong antibacterial activities against two gram-positive bacteria: B. subtilis and methicillin-resistant Staphylococcus aureus.

Product Info

Cas No.

29400-42-8

Purity

≥99%

Formula

C33H44O8

Formula Wt.

568.71

Chemical Name

(2Z)-2-[(4S,5S,6S,8S,9S,10R,13R,14S,16S)-6,16-diacetyloxy-4,8,10,14-tetramethyl-3,7-dioxo-5,6,9,11,12,13,15,16-octahydro-4H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid

IUPAC Name

(4α,5α,6β,8α,9β,13α,14β,16β,17E)-6,16-Diacetoxy-4,8,14-trimethyl-3,7-dioxo-18-norcholesta-1,17,24-trien-21-oic acid

Synonym

Fumigacin, NSC 319943, BRN 3230584

Solubility

Soluble in DMSO, acetone or chloroform. Insoluble in water.

Appearance

White to Off-White powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

H174466 MSDS PDF

Info Sheet

H174466 Info Sheet PDF

References

Ganaha M, Yoshii K, Otsuki Y, et al. In vitro antitrypanosomal activity of the secondary metabolites from the mutant strain IU-3 of the insect pathogenic fungus Ophiocordyceps coccidiicola NBRC 100683. Chem Pharm Bull (Tokyo). 2016;64(7):988-990. PMID: 27373660.

Jayanetti DR, Yue Q, Bills GF, et al. Hypocoprins A-C: new sesquiterpenoids from the coprophilous fungus Hypocopra rostrata. J Nat Prod. 2015 Mar 27;78(3):396-401. PMID: 25549014.

Ratnaweera PB, Williams DE, de Silva ED, et al. Helvolic acid, an antibacterial nortriterpenoid fmor the fungal endophyte, Xylaria sp. of orchid Anoectochilus setaceus endemic to Sri Lanka. Mycology. 2014 Mar;5(1):23-28. PMID: 24772371.

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