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CYT-387

Product ID C9876
Cas No. 1056634-68-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $92.80 In stock
5 mg $160.80 In stock
10 mg $252.70 In stock
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  • Description
  • Product Info
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  • Description
  • Product Info
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  • Downloads
  • References
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Description

CYT-387 (momelotinib) is an inhibitor of JAK2 currently under investigation as a potential treatment for myeloproliferative neoplasms; it displays anticancer chemotherapeutic activity. In cellular models of multiple myeloma, momelotinib induces G2/M phase cell cycle arrest. In vivo, this compound decreases tumor burden.

Product Info

Cas No.

1056634-68-4

Purity

≥98%

Formula

C23H22N6O2

Formula Wt.

414.46

Synonym

CYT387, CYT11387, Momelotinib

Solubility

DMSO 74 mg/mL (178.54 mM) Water Insoluble Ethanol Insoluble

Appearance

Yellow to light orange powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C9876 MSDS PDF

Info Sheet

C9876 Info Sheet PDF

References

Abubaker K, Luwor RB, Zhu H, et al. Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden. BMC Cancer. 2014 May 6;14:317. PMID: 24886434.

Geyer HL, Tibes R, Mesa RA. JAK2 inhibitors and their impact in myeloproliferative neoplasms. Hematology. 2012 Apr;17 Suppl 1:S129-32. PMID: 22507800.

Monaghan KA, Khong T, Burns CJ, et al. The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells. Leukemia. 2011 Dec;25(12):1891-9. PMID: 21788946.

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