ZM-336372 is a small molecule that acts as a tyrosine kinase inhibitor and c-Raf activator. ZM-336372 exhibits anticancer chemotherapeutic activity, increasing apoptosis, suppressing tumor growth, upregulating expression of cell cycle inhibitors, and decreasing neuroendocrine vasoactive peptide production in a variety of cell types.
| Cas No. | 208260-29-1 |
|---|---|
| Purity | ≥98% |
| Formula | C23H23N3O3 |
| Formula Wt. | 389.45 |
| Chemical Name | Benzamide, 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]- |
| IUPAC Name | 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl] benzamide |
| Solubility | DMSO 78 mg/mL (200.28 mM) Ethanol 2 mg/mL (5.13 mM) Water Insoluble |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Deming D, Geiger P, Chen H, et al. ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines. J Surg Res. 2010 Jun 1;161(1):28-32. PMID: 20031160.
Deming D, Geiger P, Chen H, et al. ZM336372, a Raf-1 activator, causes suppression of proliferation in a human hepatocellular carcinoma cell line. J Gastrointest Surg. 2008 May;12(5):852-7. PMID: 18299943.
Kappes A, Vaccaro A, Kunnimalaiyaan M, et al. ZM336372, a Raf-1 activator, inhibits growth of pheochromocytoma cells. J Surg Res. 2006 Jun 1;133(1):42-5. PMID: 16603190.
