LKT Labs

Biochemicals for Life Science Research

3-tert-Butyl-4-Hydroxyanisole

Product ID B8071
Cas No. 121-00-6
Purity ≥99% Single isomer
Product Unit SizeCostQuantityStock
5 g $142.50 In stock
10 g $255.70 In stock
50 g $828.30 In stock
Bulk Quote

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Description

3-tert-Butyl-4-hydroxyanisole (3-BHA) is one component of butylated hydroxyanisole (BHA). This compound is commonly used as a food additive; it exhibits antioxidative and anticancer activities. In leukemia cells, 3-BHA decreases the mitochondrial membrane potential, inhibits mitochondrial oxidative phosphorylation, induces apoptosis and DNA damage, and suppresses cellular proliferation. In animal models, 3-BHA induces phase II enzymes, increasing expression of quinone reductase and glutathione-S-transferase. Some studies suggest that 3-BHA may also be mutagenic.

This product contains less than 1 % 2-BHA.

Product Info

Cas No.

121-00-6
Purity

≥99% Single isomer
Formula

C11H16O2

Formula Wt.

180.25
Chemical Name

3-(1,1-Di-methylethyl)4-methoxyphenol
IUPAC Name

2-tert-butyl-4-methoxyphenol
Synonym

3-BHA
Melting Point

69-71°C
Solubility

Insoluble in water. Soluble in ethanol, acetone, DMSO.
Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

B8071 MSDS PDF
Info Sheet

B8071 Info Sheet PDF

References

Hwang GH, Jeon YJ, Han HJ, et al. Protective effect of butylated hydroxylanisole against hydrogen peroxide-induced apoptosis in primary cultured mouse hepatocytes. J Vet Sci. 2014 Oct 8. [Epub ahead of print]. PMID: 25293491.

Okubo T, Yokoyama Y, Kano K, et al. Molecular mechanism of cell death induced by the antioxidant tert-butylhydroxyanisole in human monocytic leukemia U937 cells. Biol Pharm Bull. 2004 Mar;27(3):295-302. PMID: 14993791.

Prochaska HJ, Fernandes CL. Elevation of serum phase II enzymes by anticarcinogenic enzyme inducers: markers for a chemoprotected state? Carcinogenesis. 1993 Dec;14(12):2441-5. PMID: 8269610.

Matsuoka A, Matsui M, Miyata N, et al. Mutagenicity of 3-tert-butyl-4-hydroxyanisole (BHA) and its metabolites in short-term tests in vitro. Mutat Res. 1990 Jun;241(2):125-32. PMID: 2345551.

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