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Panaxatriol

Panaxatriol

Product ID P0254
Cas No. 32791-84-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $114.20 Please Inquire
5 mg $275.10 In stock
10 mg $477.60 In stock
25 mg $954.70 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) that exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities. Panaxatriol increases expression of heme oxygenase 1 (HO-1) and activation of Nrf2 signaling in neurons in a PI3K/Akt-dependent manner. Panaxatriol also decreases acetaminophen-induced increases in ALT and TNF-α, preventing liver injury in vivo. Additionally, panaxatriol inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.

Product Info

Cas No.

32791-84-7

Purity

≥98%

Formula

C30H52O4

Formula Wt.

476.73

IUPAC Name

(3S,5R,6R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2, 6,6-trimethyloxan-2-yl]-2,3,5,6,7,9,11,12,13,15,16, 17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol

Melting Point

238-239C

Solubility

Soluble in DMSO.

Appearance

White Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P0254 MSDS PDF

Info Sheet

P0254 Info Sheet PDF

References

Huang Y, Yu J, Wan F, et al. Panaxatriol Saponins Attenuated Oxygen-Glucose Deprivation Injury in PC12 Cells via Activation of PI3K/Akt and Nrf2 Signaling Pathway. Oxid Med Cell Longev. 2014;2014:978034. PMID: 24955212.

Wang S, Wang X, Luo F, et al. Panaxatriol saponin ameliorated liver injury by acetaminophen via restoring thioredoxin-1 and pro-caspase-12. Liver Int. 2013 Sep 11. [Epub ahead of print]. PMID: 24119161.

Zhang WJ, Zhong GG, Jiang Y, et al. Single channel analysis on calcium channel blockade action of panaxadiol and panaxatriol saponins on cultured rat ventricular myocytes. Zhongguo Yao Li Xue Bao. 1994 Mar;15(2):173-6. PMID: 7516611.

Custom Order

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