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Famotidine is an antagonist at histamine H2 receptors that exhibits antacid and antioxidative activities. Famotidine inhibits gastric acid production and is clinically used to treat ulcers and gastroesophageal reflux disease (GERD). Famotidine also inhibits GSK-3β and suppresses radiation-induced DNA damage.
| Cas No. | 76824-35-6 |
|---|---|
| Purity | ≥98% |
| Formula | C8H15N7O2S3 |
| Formula Wt. | 337.45 |
| Chemical Name | 3-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]- methyl]thio-N-(aminosulfonyl)propanimidamide |
| IUPAC Name | 3-[[2-(diaminomethylideneamino)-1, 3-thiazol-4-yl]methylsulfanyl]-N'-sulfamoylpropanimidamide |
| Synonym | Amfamox, Dispromil, Famodine, Fanosin, Gaster, Motiax, Pepcid, Ulcetrax |
| Melting Point | 163-164°C |
| Solubility | Insoluble in water. Soluble in DMF. |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Mohammad M, Al-Masri IM, Issa A, et al. Famotidine inhibits glycogen synthase kinase-3β: an investigation by docking simulation and experimental validation. J Enzyme Inhib Med Chem. 2013 Aug;28(4):690-4. PMID: 22512725.
Mozdarani H, Nasirian B, Haeri SA. In vivo gamma-rays induced initial DNA damage and the effect of famotidine in mouse leukocytes as assayed by the alkaline comet assay. J Radiat Res. 2007 Mar;48(2):129-34. PMID: 17299251.